脂联素和Hs-CRP在突发性耳聋中的临床意义

目的探讨突发性耳聋患者血清脂联素和血清高敏c一反应蛋白（Hs-CRP）的含量变化，及其在突发性耳聋发生过程中的作用和意义。方法采用酶联免疫（ELISA）法检测血清脂联素含量，采用免疫比浊法对血清Hs—CRP进行测定；检测102例突发性耳聋患者、35例其他疾病对照组和30例正常健康对照组的血清脂联素和Hs-CRP含量，并比较治疗前后血清脂联素和Hs—CRP的测定结果。结果突发性耳聋患者治疗前血清Hs-CRP含量较两对照组显著升高（P〈0．01）；治疗后恢复组患者Hs-CRP含量明显降低。突发性耳聋患者治疗前血清脂联素含量较两对照组显著降低（P〈0．01）；治疗后恢复组患者脂联素含量明显升高。突发性耳聋患者血清脂联素和Hs—CRP含量之间呈负相关（r=-0．63，P〈0．01）。结论血清脂联素和Hs—CRP水平的变化与突发性耳聋病情严重程度密切相关。

Determination of serum adiponectin and high-sensitivity C-reative protein in patients with idiopathic sudden sensorineural hearing loss and its clinical significance

Objective To study the role and clinical significance of serum adiponectin and high-sensitivity C-reative protein(Hs-CRP)in idiopathic sudden sensorineural hearing loss by measuring the change of their levels in the patients with idiopathic sudden sensorineural hearing loss.Methods Adiponectin Was determined by ELISA method,Hs-CBP was determined by rate nephelometry immunoassuy.The levels adiponectin and Hs-CRP were determined in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points:before and after treatment,and thirty-five patients with other neurologic diseases(20with sciatica,16withtrigeminal neuralgia)and thirty healthy people were used as control.Results The levels of Hs-CRP in serum of patients with idiopathic sudden sensorineural hearing loss were markedly higher than those in the two control groups(P<0.01);the levels of Hs-CRP in the idiopathic sudden sensorineural hearing loss group after treatment were significantly less than that before treatment(P<0.01).The levels adiponectin in serum of pailents with idiopathic sudden sensorineural hearing loss were markedly lower than those in the two control groups(P<0.01);the levels of adiponectin in the idiopathic sudden sensorineural hearing loss group after treatment were significantly higher than that before treatment(P<0.01).There was negatively correlation between adiponectin and Hs-CRP in patients with idiopathic sudden sensorineural hearing loss(r=-0.63,P<0.01).Conclusion The levels of serum adiponectin and Hs-CRP have instructive significance in idiopathic sudden sensorineural hearing loss treating and prognosis estimating.