家族性结肠腺瘤病—家系分析

本文报道FP一个家族4代13人,发病5人,1人已有二处癌变,与常染色体显性遗传律完全相符。该病主诉多以粘液血便为主,发生时间也很不相同,极易癌变。其特点是癌变早,癌变率高,可多中心同时发生。治疗上作者推荐用全结肠和直肠粘膜切除,经直肠腔内施出回肠,行回肛吻合术。以免腺瘤复发和癌变。

Analysis of Familial Polyposis in a Family

This article reports a family of four generations comprised of 13 persons, 5 of which developed familial polyposis(FP). One of the 5 cases had two carcinomatous foci. It tallies well with the law of autosomal dominant heredi- ty. The chief complaint of the patients was mucous bloody stools. The rate of transforming into malignancy was very high. 1n general,malignant transformation takes place at a younger age and manifests with multiple foci. Colectomy and a pull-through lleoanostomy is usually advisable In order to avoid relapse and malignant transformation of the adenomata.