EGFR/HER1和C-erb B-2/HER2在乳腺癌表达的意义及其相关性

目的：探讨乳腺癌中EGFR和C—erbB-2基因蛋白表达的临床意义。方法：乳腺癌86例，乳腺腺瘤36例，采用免疫组织化学方法，检测EGFR／HER。和C—erbB-2／HER：阳性率，分析它们的相关性。结果：EGFR和C—erbB-2在乳腺癌中的表达高度正相关（r=0、73）。它们在乳腺癌中的阳性率明显高于腺瘤（P〈0．001）。在乳腺癌中EGFR和C—erbB-2的阳性率分别为56．98％（49／86）和70．93％（61／86），差异无显著性（P〉0．05）。在浸润癌和有淋巴结转移组阳性率高于非浸润组和无淋巴结转移组（P〈0．001）。结论：EGFR和C—erbB-2在乳腺癌发生中有协同作用，是预后不良的指标。

Clinical significance and their relation of EGFR and C-erb B-2 expression in breast carcinoma

Objective:To study the significance of epidermal growth factor receptor(EGFR/HER1) and C-erb B-2(HER2) gene protien overexpression in breast carcinoma.Methods:Thirty six cases of adenoma and 86 cases of breast cancer were detected by SP immunohistochemistry.The relation of their expression were analysed.Results:EGFR was correlated with C-erb B-2 in breast carcinoma(r=0.70).The positive rates of EGFR and C-erb B-2 were 56.98%(49/86) and 70.93(61/86)(P>0.05).The expression rates of EGFR and C-erb B-2 in the group of lymphnode metastasis and group of invasive cancer were higher than nonlymphnode metastasis and noninivasive cancer(P<0.01).Conclusion:The EGFR and C-erb B-2 have combined effect for occurrence of breast cancer and they are predictive factors for breast cancer.