斑驳病患者头发7种微量元素的测定

采用电感耦合等离子体发射光谱法（ＩＣＰ－ＡＥＳ）对６例斑驳病患者和３１例正常对照的头发标本中７种微量元素进行测定．结果表明，本病患者发中Ｚｎ和Ｃｕ的含量显著低于正常对照组（分别为９４．２３±７．６２ｐｐｍ和１３８．７８±１１．２４ｐｐｍ；８．９１±１．２７ｐｐｍ和１１．５７±７．８７ｐｐｍ；Ｐ＜０．０５）．而发Ｆｅ含量增高显著（分别为２７．５２±１０．２１ｐｐｍ与１４．９１±８．８９ｐｐｍ，Ｐ＜０．０１）；发Ｃｒ、ｃｄ、Ｐｂ、Ｓｅ的含量差异无显著性．同时进行的细胞遗传学研究未发现患者有异常核型．我们认为，由斑驳病基因突变或缺失所致黑色素细胞游走成分化受累以及患者体内Ｚｎ、Ｃｕ和Ｆｅ含量的异常是本病发生的一种诱因．

Measure of Concentrations of Seven Trace Elements in Hair in Piebaldism

The piabaldism is a disorder in which the major clinical features are patchy hypopigmentation of the skin and a white forelock.It is an autonomous autosomal dominant entitv, The concentrations of seven trace elements(Zn,Cu,Fe,Cr,Cd,Pb and Se)in hair in 6 patients and 31 normal persons were determined with ICP- AES method.The results showed that the concentrations of copper and zinc in patients were significatly lower than those of the control(94.23±7.62 ppm vs 138.78±11.24 ppm,P<0.05;8.91±1.27 ppm vs 11.57±7.87 ppm,and P<0.05,especially),but the concentration of iron was significatly higher(27.52±10.21 ppm vs 14.91±8.89 ppm P<0.01 )than that in the control;the others were normal.We also analysed the chromosome karyotypes in 6 patients.No chromosome aberrations were found.The data suggests that the mutation of piebald trait gene and the changes in some trace elements be the reason for piebaldism.