| 地塞米松对Masugi肾炎的治疗作用 |
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| 引用本文： | 黎七雄,彭仁琇,汪晖,丁虹,孔锐. 地塞米松对Masugi肾炎的治疗作用[J]. 华西药学杂志, 2000, 15(3): 220-221 |
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| 作者姓名： | 黎七雄 彭仁琇 汪晖 丁虹 孔锐 |
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| 作者单位： | 湖北医科大学药理教研室,武汉,430071 |
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| 摘 要： | 目的：观察地塞米松对Ｍａｓｕｇｉ肾炎的治疗作用。方法：建立Ｍａｓｕｇｉ肾炎模型,观察Ｍａｓｕｇｉ肾炎尿蛋白、ＢＵＮ、ＳＣｒ含量的动态变化及组织形态学的改变。结果：地塞米松处理的家兔尿蛋白、ＢＵＮ、ＳＣｒ含量均明显低于Ｍａｓｕｇｉ肾炎模型组（Ｐ〈０．００１）,也未见有明显的肾小球理性损害。结论：地塞米松对Ｍａｓｕｇｉ肾炎具有很好的治疗作用。
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| 关 键 词： | 地塞米松 Masugi肾炎 药物疗法 |
THE THERAPEUTIC EFFECT OF DEXAMETHASONE ON MASUGI GLOMERULONEPHRITICS(MGN) |
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| LI Qi-xiong,PENG Ren-xiu,WANG Hui,DING Hong,KONG Rui. THE THERAPEUTIC EFFECT OF DEXAMETHASONE ON MASUGI GLOMERULONEPHRITICS(MGN)[J]. West China Journal of Pharmaceutical Sciences, 2000, 15(3): 220-221 |
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| Authors: | LI Qi-xiong PENG Ren-xiu WANG Hui DING Hong KONG Rui |
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| Abstract: | OBJECTIVE:The effect of Dexamethasone was observed on the experiments MGN models of rabbitis.METHODS:The Model of MGN was established in rabbitis,the Urine protein,BUN,SCr levels were determined in MGN.Simultaneously,Pathologic changes were observed in MGN.RESULTS:The Urine protein content was increased significantly in 715 days and the BUN,SCr levels were also significantly elevated in 1015 days after MGN were established,glomerule proliferation and fibrosis as well as crescent were produced.The levels of Urine protein,BUN,SCr in group treated by the Dexamethasone were apparently lower than that in group of MGN(P<0001),glomerule cells were not pathologic damages.CONCLUSION:The therapeutic effect of Dexamethasone on MGN is very good. |
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| Keywords: | Dexamethasone Masugi Glomerulonephritis Therapeutic effect |
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