REM sleep deprivation induces a decrease in norepinephrine-stimulated 3H-cyclic AMP accumulation in slices from rat brain |
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| Authors: | L R Troncone S Braz M A Benedito S Tufik |
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| Affiliation: | 1. Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA;2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;3. Taub Institute for Research on Alzheimer''s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA;4. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA;5. Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA;6. Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT, USA;7. Department of Social and Behavioral Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA;1. University Grenoble Alpes, HP2, Inserm 1042, Grenoble F-38042, France;2. Physiology Sleep and Exercise Clinic, Thorax and Vessel division, Grenoble Alpes hospital, Grenoble 38043, France;3. Pulmonary Physiology Laboratory, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United States |
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| Abstract: | Beta adrenergic sites in rat brain are reduced after repeated treatment with antidepressant drugs, with REM sleep deprivation (REMSd) having the same effect. This paper reports the effects of REMSd in the production of 3H-cyclic AMP in frontal cortical slices by NE challenge. Data presented in this paper report a marked decrease in 3H-cyclic AMP synthesis after REMSd, which is in accordance with previous results showing adrenergic receptor down-regulation following REMSd. Results are discussed in view of possible interaction with dopaminergic systems and depression management. |
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