妇科养荣胶囊联合炔诺酮治疗更年期功能性子宫出血临床效果分析

目的观察更年期功能性子宫出血(功血)患者采用中西医联合治疗的临床效果。方法选取2011年3月至2013年3月保定市清苑县妇幼保健院接诊的150例更年期功血患者作为研究对象,随机数字表法分为A、B、C组,各50例,其中A组采用中药补肾益气固冲汤治疗,B组采用西药炔诺酮治疗,C组采用妇科养荣胶囊联合炔诺酮治疗。对比三组患者的临床治疗效果,在治疗第1日、第2日及第3日的出血控制率、完全止血率、完全止血时间及用药后的不良反应等情况。结果 C组总有效率为98%,显著高于A组的86%和B组的88%(P<0.05)。C组完全止血率为92%,显著高于A组的46%和B组的66%(P<0.05);A组显著低于B组(46%vs 66%,P<0.05)。安全止血时间A组为(86.8±14.8)h、B组为(54.8±15.3)h、C组为(46.4±12.8)h,三组比较差异有统计学意义,并且A组显著长于B组,C组显著短于A组和B组(P<0.05);A组患者用药后不规则出血的发生率显著高于B组(26%vs 14%,P<0.05),C组无不规则出血表现;B组有7例患者出现恶心症状,A组与C组未出现恶心症状。结论中西医结合治疗更年期功血相比单纯中医或西医治疗的临床效果更佳,且不良反应少,值得临床推广。

Analysis on the Clinical Effect Fukeyangrong Capsule Combined with Norethindrone for Menopause Dysfunctional Uterine Bleeding

Objective To observe the clinical effects of combined treatment of traditional Chinese and Western medicine for treating perimenopausal dysfunctional uterine bleeding（DUB）. Methods A total of 150 cases of menopause dub patients in Baoding City Qingyuan from Mar. 2011 to Mar. 2013 were included in the study, and were randomly divided into group A, group B, and group C ,50 cases in each group;group A was treated with kidney and Qi tonifying decoction, group B was treated with norethisterone, group C was treated with Fukeyangrong capsule combined with norethisterone, and the clinical curative effect of the three groups was compared, at the first day, second day and third day of treatment, the bleeding control rate, complete hemostasis rate, complete hemostasis time, and adverse reactions were compared. Results The total effective rate in group C （98%）was sigrtificantly higher than group A （86%） and group B （88%） （P 〈 0.05 ）. Complete hemostasis rate in group C （ 92% ） was significantly higher than group A （ 92% ） and group B （66%） （P 〈0.05 ）, complete hemostasis rate in group A were significantly lower than group B （46% vs 66 %, P 〈 0.05 ）. Safe hemostasis time of group A was （ 86.8 ±14.8 ） h, of group B was （ 54.8 ± 15.3 ） h, of group C was （46.4 ±12.8 ）h,group A was significantly longer than group B, group C was significantly shorter than group A and B （P 〈 0. 05 ） ;the incidence of irregular bleeding medication of group A was 26% , higher than group B（ 14% , ） ,no irregular bleeding manifestation was observed in group C; 7 patients in group B had symptoms of nausea,no nausea symptoms observed in group A and C. Conclusion Compared with the pure Chinese medicine or western medicine, the clinical effect of integrated traditional Chinese and western medicine treatment for menopausal dysfunctional uterine bleeding is better with less adverse reactions, thus is worth the clinical promotion.