| 中国株庚型肝炎病毒(HGV)感染猕猴的实验研究 |
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| 引用本文： | 汪兴太,庄辉,李河民,李奎,祁自柏,朱万孚,朱永红,蓝海云,林京香.中国株庚型肝炎病毒(HGV)感染猕猴的实验研究[J].中华微生物学和免疫学杂志,1997(5). |
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| 作者姓名： | 汪兴太 庄辉 李河民 李奎 祁自柏 朱万孚 朱永红 蓝海云 林京香 |
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| 作者单位： | 中国药品生物制品检定所，北京医科大学微生物学系 |
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| 摘 要： | 应用０．５ｍｌ含中国株庚型肝炎病毒（ＨＧＶ）的血清接种５只猕猴，５只猕猴于接种后１周血清ＨＧＶＲＮＡ均阳转；ＨＧＶＲＮＡ滴度在猴体内可高达１∶１０５，较接种血清中ＨＧＶＲＮＡ滴度（１∶１０２）高出许多，提示ＨＧＶ在猕猴体内复制。其中４只猕猴血清抗－ＨＧＶ阳转；４只出现ＡＬＴ异常。后用其中１只猕猴感染后４５天的血清给另２只猕猴接种，该２只猴也出现血清ＨＧＶＲＮＡ和抗－ＨＧＶ阳转及ＡＬＴ异常。本研究表明，中国猕猴有可能作为ＨＧＶ感染的动物模型。
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| 关 键 词： | 庚型肝炎病毒 动物模型 聚合酶链反应 |
Macaca mulatta as an animal model for HGV infection |
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| Wang Xingtai,Zhuang Hui,Li Hemin,et al..Macaca mulatta as an animal model for HGV infection[J].Chinese Journal of Microbiology and Immunology,1997(5). |
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| Authors: | Wang Xingtai Zhuang Hui Li Hemin |
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| Institution: | Wang Xingtai,Zhuang Hui,Li Hemin,et al.National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050 |
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| Abstract: | Macaca mulatta were inoculated with 0.5ml HGV RNA positive serum collected from a patient with hepatitis G.HGV RNA of all 5 monkeys converted to positive within 1 week after inoculation and increased appearently.Anti HGV seroconvertion was found in 4/5 of the monkeys from 15 to 45 days postinfection,and 4/5 of the monkeys had abnormal levels of ALT after infection.A HGV RNA positive serum obtained from one of the infected monkeys was used to infect other two monkeys.HGV RNA and anti HGV seroconversion,and ALT elevation were also observed in these two monkeys.The results showed that the Macaca mulatta may be used as an experimental animal model for HGV infection. |
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| Keywords: | HGV Macaca mulatta Animal model PCR |
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