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| 各型甲状腺肿瘤组织中生长抑素受体的表达 | |
| 引用本文： | 潘卫民,谭天秩,吴华,张春,龚日祥,刘卫平,孙龙,苏新辉,彭添兴,陈贵兵,罗作明,严和平,魏继红.各型甲状腺肿瘤组织中生长抑素受体的表达[J].中国医学影像技术,2009,25(6):1085-1088. |
| 作者姓名： | 潘卫民 谭天秩 吴华 张春 龚日祥 刘卫平 孙龙 苏新辉 彭添兴 陈贵兵 罗作明 严和平 魏继红 |
| 作者单位： | 1. 福建医科大学附属厦门第一医院核医学科,福建,厦门,361003;四川大学华西医院核医学科,四川,成都,610041 2. 四川大学华西医院核医学科,四川,成都,610041 3. 福建医科大学附属厦门第一医院核医学科,福建,厦门,361003 4. 四川大学华西医院普外科,四川,成都,610041 5. 四川大学华西医院病理科,四川,成都,610041 |
| 摘 要： | 目的 用原位杂交方法 观察生长抑素受体在甲状腺肿瘤组织及癌旁组织中的表达.方法 根据生长抑素受体(SSTR)亚型的基因结构设计两种cDNA探针:针对各型生长抑素受体的寡核苷酸探针以及特异性针对二型生长抑素受体(SSTR2)的寡核苷酸探针序列,并分别与各型甲状腺肿瘤组织及癌旁组织行原位杂交,采用Mias图像分析仪进行灰度分析, mRNA丰度以信号强度x-±s表示,进行t检验.结果 甲状腺髓样癌组织中SSTR的表达明显高于癌周组织(P＜0.05),SSTR2仅在癌组织中有表达.SSTR在甲状腺乳突状癌组织中的表达明显高于癌周组织(P＜0.05),SSTR2在癌组织及癌周组织内均未见有表达.滤泡性腺癌组织SSTR的表达明显高于癌周组织(P＜0.05),癌组织及癌周组织均未见有SSTR2表达.嗜酸性细胞癌组织SSTR的表达明显高于癌周组织(P＜0.05),SSTR2仅在癌组织中有表达.结论 SSTR2仅在MTC及HCC的肿瘤组织中有表达;各型甲状腺肿瘤组织均表达除SSTR2之外的其他几型SSTR中的一种或数种,且肿瘤组织中的表达强度明显高于邻近正常组织.某些靶向生长抑素受体(尤其是特异性靶向SSTR2)的化合物(配体),可能成为甲状腺肿瘤尤其是甲状腺髓样癌和嗜酸性细胞癌的特异性显像剂和靶向治疗载体. |
| 关 键 词： | 甲状腺肿瘤 生长抑素受体 原位杂交 受体显像 |
| 收稿时间： | 2008/10/23 0:00:00 |
| 修稿时间： | 2008/11/27 0:00:00 |
Expression of somatostatin receptor in human thyroid carcinoma |
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| PAN Wei-min,TAN Tian-zhi,WU Hu,ZHANG Chun,GONG Ri-xiang,LIU Wei-ping,SUN Long,SU Xin-hui,PENG Tian-xing,CHEN Gui-bing,LUO Zuo-ming,YAN He-ping and WEI Ji-hong.Expression of somatostatin receptor in human thyroid carcinoma[J].Chinese Journal of Medical Imaging Technology,2009,25(6):1085-1088. | |
| Authors: | PAN Wei-min TAN Tian-zhi WU Hu ZHANG Chun GONG Ri-xiang LIU Wei-ping SUN Long SU Xin-hui PENG Tian-xing CHEN Gui-bing LUO Zuo-ming YAN He-ping and WEI Ji-hong |
| Institution: | Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China;Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China;Department of Surgery, West China Hospital of Sichuan University, Chengdu 610041, China;Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China;Department of Nuclear Medicine, the First Hospital of Xiamen, Affiliated Hospital of Fujian Medical University, Xiamen 361003, China |
| Abstract: | |
| Keywords: | Thyroid neoplasms Somatostatin receptor In situ hybridization Receptor scintigraphy |
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