| 形状记忆聚合物聚醚多元醇-异氰酸酯的组织相容性 |
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| 引用本文： | 文英,陈丹,贺素媛,蒋学俊,胡金莲,黄华华,李晓艳,任珊.形状记忆聚合物聚醚多元醇-异氰酸酯的组织相容性[J].武汉大学学报(医学版),2012,33(3):359-362. |
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| 作者姓名： | 文英 陈丹 贺素媛 蒋学俊 胡金莲 黄华华 李晓艳 任珊 |
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| 作者单位： | 文英 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； 陈丹 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； 贺素媛 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； 蒋学俊 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； 胡金莲 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； 黄华华 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； 李晓艳 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； 任珊 (武汉大学人民医院心内科211实验室,湖北武汉,430060) ； |
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| 基金项目： | 国家大学生创新实验项目 |
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| 摘 要： | 目的:探讨新型形状记忆聚合物(SMP)聚醚多元醇-异氰酸酯(PTMEG-MDI)的生物安全性及组织相容性,为其应用于生物医学领域提供理论依据。方法:将PTMEG-MDI植入实验组大鼠后肢皮下,对照组仅进行手术操作,不埋植PTMEG-MDI,分别于术后3d及1,2,4周抽血行血常规及肝肾功能检测,HE切片行组织学检查。结果:两组动物血常规及肝肾功能指标无显著性差异,病理组织切片示材料植入后周围组织反应符合一般炎症变化的转归规律。结论:新型形状记忆聚合物PTMEG-MDI具有良好的生物安全性及组织相容性,可应用于生物医学领域。
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| 关 键 词： | 形状记忆聚合物 聚氨酯 生物相容性 |
Histocompatibility of Shape-Memory Polymer PTMEG-MDI |
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| WEN Ying,CHEN Dan,HE Suyuan,JIANG Xuejun,HU Jinlian, HUANG Huahua,LI Xiaoyan,REN Shan.Histocompatibility of Shape-Memory Polymer PTMEG-MDI[J].Medical Journal of Wuhan University,2012,33(3):359-362. |
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| Authors: | WEN Ying CHEN Dan HE Suyuan JIANG Xuejun HU Jinlian HUANG Huahua LI Xiaoyan REN Shan |
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| Institution: | Dept.of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China |
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| Abstract: | Objective: To investigate the bio-safety and histocompatibility of PTMEG-MDI,a new shape-memory polymer,in order to provide the theoretical background for biomedical application.Methods: PTMEG-MDI was implanted subcutaneously in rats’ hind limb as treatment,while nothing was implanted but surgery only served as control.Blood routine,liver and kidney function,and histological examination were tested in three days,one week,two weeks and four weeks after surgery.Results: There is no significant difference in blood routine,liver and kidney function between the treatment group and control group.Histological analysis indicates that the inflammatory response of the implanted PTMEG-MDI fits the general rule of the inflammation.Conclusion: New shape memory polymer PTMEG-MDI has a satisfactory bio-safety and histocompatibility and can be used as a new biomedical material. |
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| Keywords: | Shape-Memory Polymer Polyurethane Biocompatibility |
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