| 消旋卡多曲对秋季腹泻的治疗作用及对血清中IL-1、IL-8和IL-12的影响 |
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| 引用本文： | 边俊梅,王瑢,张蔷,周晓光. 消旋卡多曲对秋季腹泻的治疗作用及对血清中IL-1、IL-8和IL-12的影响[J]. 武汉大学学报(医学版), 2012, 33(3): 384-386 |
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| 作者姓名： | 边俊梅 王瑢 张蔷 周晓光 |
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| 作者单位： | 边俊梅 (武汉市第三医院光谷关山院区儿科,湖北武汉,430074) ； 王瑢 (武汉市第三医院光谷关山院区儿科,湖北武汉,430074) ； 张蔷 (武汉大学医学院,湖北武汉,430071) ； 周晓光 (南京市儿童医院,江苏南京,210029) ； |
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| 摘 要： | 目的:探讨消旋卡多曲辅助治疗秋季腹泻患儿的效果,探讨治疗后血清中白细胞介素-1(IL-1)、白细胞介素-8(IL-8)和白细胞介素-12(IL-12)为主的炎性因子的变化,以期为临床治疗提供帮助。方法:选取138例在我院确诊为秋季腹泻的患儿,随机分为两组,观察组69例,在常规治疗基础上加用消旋卡多曲治疗,对照组69例,应用常规治疗,并对两组的治疗效果及两组病例治疗前后血清中IL-1、IL-8和IL-12的表达进行分析。结果:观察组疗效明显高于对照组,治疗后观察组患儿血清中IL-1、IL-8和IL-12的表达明显低于对照组。结论:秋季腹泻患儿在常规治疗基础上加用消旋卡多曲的治疗效果好,且能有效调节血清中IL-1、IL-8和IL-12的表达,有效抑制机体的炎性环境,可用于临床辅助治疗。
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| 关 键 词： | 秋季腹泻 消旋卡多曲 白细胞介素-1 白细胞介素-8 白细胞介素-12 临床疗效 |
Clinical Effect of Racecadotril Granules and the Impact on Serum IL-1,IL-8,and IL-12 Levels in Children with Autumn Diarrhea |
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| BIAN Junmei,WANG Rong,ZHANG Qiang,ZHOU Xiaoguang. Clinical Effect of Racecadotril Granules and the Impact on Serum IL-1,IL-8,and IL-12 Levels in Children with Autumn Diarrhea[J]. Medical Journal of Wuhan University, 2012, 33(3): 384-386 |
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| Authors: | BIAN Junmei WANG Rong ZHANG Qiang ZHOU Xiaoguang |
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| Affiliation: | 1Dept.of Paediatrics,The Third Hospital of Wuhan,Wuhan 430074,China; 2School of Medicine,Wuhan University,Wuhan 430071,China; 3Nanjing Children’s Hospital,Nanjing 210029,China |
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| Abstract: | Objective: To observe the curative effect of Racecadotril Granules in children with autumn diarrhea,and to study whether it has impact on the serum levels of IL-1,IL-8 and IL-12.Methods: A total of 69 autumn diarrhea cases were treated with Racecadotril Granules and the clinical outcomes were compared with those of the control group without Racecadotril treatment.The serum levels of IL-1,IL-8 and IL-12 were detected in both groups.Results: The total effective rate was obviously higher in the observation group than in the control group.The serum levels of IL-1,IL-8,and IL-12 were obviously lower in Racecadotril group than in the control group after treatment.Conclusion: Racecadotril Granules can improve the curative effect and regulate the expression of IL-1,IL-8 and IL-12 in children with autumn diarrhea. |
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| Keywords: | Autumn Diarrhea Racecadotril Granules IL-1 IL-8 IL-12 Clinical Effect |
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