奥沙拉嗪口服联合灌肠治疗溃疡性结肠炎疗效观察

目的观察奥沙拉嗪胶囊口服联合保留灌肠治疗溃疡性结肠炎（UC）的疗效和安全性。方法71例UC患者随机分为A（37例）、B（34例）两组，分别给予奥沙拉嗪和艾迪莎口服联合保留灌肠，给药4周。结果治疗后两组症状均显著改善（P〈0．05），A组腹痛、腹泻及黏液血便的改善情况虽优于B组，但差异均无统计学意义（P〉0．05）；A组总有效率虽高于B组（95．9％vs91．2％），但差异无统计学意义（P〉0．05），但A组显效率显著高于B组（51．4％vs41．2％）（P〈0．05）；无严重不良反应。结论奥沙拉嗪和艾迪莎口服联合保留灌肠均有较好疗效，但奥沙拉嗪又表现出可提高显效率的优势。

The efficacy investigation of Olsalazine oral and enema on treatment of ulcerative colitis

Objective To investigate the efficacy and the safety of olsalazine oral and enema on ulcerative colitis(UC) Methods 71 cases with UC were divided into A group(37)and B group(34),and oral and enema Olsalazine or Etiasa,respectively.Results The symptoms were significantly improved in two groups(P < 0.05).Compared with B group,the symptom of A group were not significant(P > 0.05).Compared with B group,the total effective patients was not significantly improved(95.9% vs 91.2%),but excellence rat was significantly improved(P < 0.05)(51.4% vs 41.2%).No severe complications were observed in all cases during treatment.Conclusion Oraled and Enema Olsalazine or Etiasa can receive efficacy on UC.The Olsalazine has particular advantage on excellence rate.