Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients |
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| Authors: | U Pugazhenthi K Velmurugan A Tran G Mahaffey S Pugazhenthi |
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| Institution: | (1) Section of Endocrinology, Veterans Affairs Medical Center, Denver, CO, USA;(2) Department of Medicine, University of Colorado Denver, Mail Stop 8106, 12801 E 17th Ave, Aurora, CO 80045, USA; |
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| Abstract: | Aims/hypothesis Exendin-4, a glucagon-like peptide-1 (GLP-1) analogue, is reported to have modest anti-inflammatory effects in addition to
that of improving beta cell survival. We therefore sought to determine whether exendin-4 decreases expression of the gene
encoding chemokine (C-X-C motif) ligand (CXCL)10, which plays a role in initiating insulitis in type 1 diabetes. |
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