温脾汤对腺嘌呤性慢性肾衰竭大鼠肾功能的保护作用

目的:观察温脾汤对大鼠腺嘌呤性慢性肾衰竭的防治作用。方法:将SD大鼠随机分为正常组、假手术组、模型组、尿毒清组及温脾汤小、中、大剂量组。尿毒清组及温脾汤小、中、大剂量组,用200 mg/kg腺嘌呤水溶液及尿毒清、温脾汤不同剂量灌胃,共4周。在第2周和第4周时留取每组大鼠的24 h尿液、称重,第4周处死大鼠,取血、留取肾组织。测定尿、血Ca2+、P3+及血SCr、BUN,进行统计学处理。结果:温脾汤组对慢性肾衰竭大鼠的尿、血Ca2+、P3+及血SCr、BUN有不同程度的改善,疗效明显优于模型组。结论:温脾汤对腺嘌呤导致的大鼠慢性肾衰竭有一定的保护作用。

PROTECTION EFFECT OF WENPI DECOCTION ON RENAL FUNCTION OF CHRONIC RENAL FAILURE DUE TO ADENINE

Objective:to observe the effects of wenpi decoction in protecting and curing chronic renal failure(CRF) due to adenine.Methods:SD rats were divided into 7 groups:normal group,artioperation group,model group,niaoduqing control group,low,middle,high dosage of wenpi decoction groups.The niaoduqing group and three dosage of wenpi decoction groups rats were filled the stomach by adenine,niaoduqing and wenpi decoction for 4 weeks. At the second and fouth weeks,24 hours'urine of every group was collected and weighted.After 4 weeks,the rats were killed and the kidney and blood were used for analysis,the serum is separated,the related indexes calcium ion(Ca~(2+)),phosphorus ion(P~(3+)),creatinine of blood,blood urea nitrogen were measured and analyzed by using SPSS system.Results:from the related indexes(Ca~(2+),P~(3+)creatinine of blood,blood urea nitrogen),it is pointed out that wenpi decoction can improve the condition of the CRF rats,and has the similar effect on the control group.Conclusion: wenpi decoction can improve the renal function caused by metabolic products in adenine-modeled CRF rats.