| 大黄素衍生物的合成及其应用研究进展 |
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| 引用本文： | 邱炳林,张风森,王文峰.大黄素衍生物的合成及其应用研究进展[J].海峡药学,2010,22(1):6-12. |
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| 作者姓名： | 邱炳林 张风森 王文峰 |
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| 作者单位： | 福州大学化学化工学院,福州,350108 |
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| 基金项目： | 福建省青年人才基金资助项目(2007F3048) |
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| 摘 要： | 大黄素拥有利尿、引起血管舒张、抗菌、抗病毒、抗肿瘤等多种生物活性。但由于大黄素本身水溶性差、毒副作用大等缺点．近年来对大黄素的结构修饰得到了广泛的关注。本文综述了近年来国内外大黄素衍生物的最新合成进展，重点介绍一些具有较高生物活性的大黄素衍生物的合成报道。
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| 关 键 词： | 大黄素 衍生物 合成 光力学治疗 |
Research progress on synthesis and application of emodin derivatives |
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| QIU Bing-lin,ZHANG Feng-sen,WANG Wen-feng.Research progress on synthesis and application of emodin derivatives[J].Strait Pharmaceutical Journal,2010,22(1):6-12. |
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| Authors: | QIU Bing-lin ZHANG Feng-sen WANG Wen-feng |
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| Institution: | Department of Chemistry;Fuzhou University;Fuzhou 350108;China |
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| Abstract: | Emodin posses diuretic and vasodilatatoric effects as well as antibiotic,antiviral anti-neoplastic and anti-tumor activity.However,emodin has characteristic of bad water-solubility and high side-effect.Therefore,modifing the structure of emodin becomes the hot topic in recent years.The article reviews the development of synthesizing emodin derivatives at home and abroad in recent years,focuses on some of the higher biological activity of emodin derivatives reported. |
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| Keywords: | Emodin Derivatives Synthesis Photodynamic therapy |
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