| 肾上腺髓质素及其受体在增生性玻璃体视网膜病变前膜中的表达 |
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| 引用本文： | Huang W,Wang L,Yuan M,Ma JX,Hui YN. 肾上腺髓质素及其受体在增生性玻璃体视网膜病变前膜中的表达[J]. 中华眼科杂志, 2004, 40(5): 317-320 |
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| 作者姓名： | Huang W Wang L Yuan M Ma JX Hui YN |
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| 作者单位： | 1. 710032,西安第四军医大学西京医院眼科研究所
2. 710032,西安第四军医大学西京医院心脏内科研究所 |
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| 基金项目： | 国家自然科学基金资助项目 (3 9970 780 ) |
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| 摘 要： | 目的 探讨肾上腺髓质素(ADM)及其受体(ADMR)在增生性玻璃体视网膜病变(PVR)前膜中的表达。方法 标本取自2001年7-11月在我院眼科研究所确诊为孔源性视网膜脱离合并PVR行玻璃体手术的10例连续病例,PVR均为C级以上,采用原位杂交法对术中所取标本的ADM和ADMR mRNA表达情况进行观察。结果10例增生性玻璃体视网膜病变前膜中有7例ADM和ADMR mRNA阳性。阳性细胞内分布不均匀,部分细胞以胞质阳性为主,部分细胞的阳性主要出现在胞核。结论 ADM和ADMR在PVR前膜中表达,PVR的发病过程中有ADM和ADMR的参与。(中华眼科杂志,2004,4D：317-320)
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| 关 键 词： | 肾上腺髓质素 肾上腺髓质素受体 增生性玻璃体视网膜病变 孔源性视网膜脱离 原位杂交法 |
Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy |
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| Huang Wei,Wang Lin,Yuan Ming,Ma Ji-xian,Hui Yan-nian. Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy[J]. Chinese Journal of Ophthalmology, 2004, 40(5): 317-320 |
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| Authors: | Huang Wei Wang Lin Yuan Ming Ma Ji-xian Hui Yan-nian |
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| Affiliation: | Institute of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. |
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| Abstract: | Objective To investigate the expression of adrenomedullin (ADM) and ADM receptor (ADMR) in epiretinal membrances (ERM) of proliferative vitreoretinopathy (PVR). Methods The expression of ADM and ADMR in 10 ERM were studied by in situ hybridization analysis (ISH). Results ADM and ADMR mRNAs were expressed in 7 of 10 specimens. The positive signals were distributed unevenly in positive cells. Some cells expressed mainly in the cytoplasm and the others expressed mainly in the nucleus. Conclusion ADM and ADMR are expressed in the ERM of PVR,indicating that ADM and ADMR may play a role in the pathogenesis of PVR. |
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| Keywords: | Vitreoretinophty prolifercctive Peptides Receptors peptide in situ hybridization |
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