Interleukin-10 and Interleukin-1 receptor antagonists increase during cardiac surgery |
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Authors: | Takae Kawamura Reiji Wakusawa Katsuya Inada |
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Institution: | (1) Department of Anacsthesiology, School of Medicine, Iwate Medical University, 19-1, Uchimaru, Morioka, 020 Iwate, Japan |
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Abstract: | Background It has been reported that inflammatory cytokines such as interleukin-8 and 6 (IL-8, IL-6) increase during cardiac surgery and cause postoperative cardiac dysfunction. Therefore, it is important to investigate changes of suppressive cytokines such as IL-10, interleukin-4 (IL-4) and interleukin-1 receptor antagonist (IL-1 ra) dunng cardiac surgery. Method Serum levels of cytokines and IL-1 ra were measured in 10 patients during cardiac surgery with cardiopulmonary bypass. Six blood samples were drawn after inducing anaesthesia. In each sample, serum IL-10, IL-4, IL-8, IL-6 and IL-1 ra were measured by enzyme linked immunosorbent assay. Results Serum IL-6 and IL-8 concentration (19.1 ±8.8 pg · ml?1, and 13.4±5.2 pg · ml?1, preoperatively) increased to 227.5± 191 pg · ml?1 and 81.0±56 pg · ml?1 at 60 min after declamping the aorta (P< 0.01, respectively). Serum IL-10 concentration increased at 60 min after dedamping the aorta compared with the preoperative value (from 1.0±0 pg · ml?1 to 552.0± 158 pg · ml?1 P< 0.001]). Similarly, serum IL-1 ra concentration increased from the preoperative value of 1331±896 pg · ml?1 to 43353±12812 pg · ml?1 at 60 min after dedamping the aorta (P< 0.00l). Positive correlations were obtained between IL-10 and IL-8. and between IL-10 and IL-6 (γ=0.7, γ=0.8, P< 0.001, respectively). Conclusion These findings demonstrate that pro-and anti-inflammatory cytokines increase to maintain their balance during cardiac surgery. |
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