| 基于肠道菌群研究两亲性嵌段共聚物用于汤剂抑苦的适宜性 |
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| 引用本文： | 林俊芝,李潘,仇敏,柯秀梅,韩丽,杨明,伍振峰,张定堃.基于肠道菌群研究两亲性嵌段共聚物用于汤剂抑苦的适宜性[J].中草药,2021,52(1):65-74. |
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| 作者姓名： | 林俊芝 李潘 仇敏 柯秀梅 韩丽 杨明 伍振峰 张定堃 |
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| 作者单位： | 成都中医药大学附属医院 中心实验室, 四川 成都 610072;成都市青白江区人民医院, 四川 成都 610300;成都中医药大学 西南特色中药资源省部共建国家重点实验室, 四川 成都 611137;重庆医科大学中医药学院, 重庆 400016;江西中医药大学 现代中药制剂教育部重点实验室, 江西 南昌 330004 |
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| 基金项目： | 国家自然科学基金项目（81803745）；四川省科技厅青年杰出科技人才资助项目（2019JDJQ0007）；2019-2021年度中华中医药学会青年人才托举工程项目（2019-QNRC2-B05）；江西中医药大学现代中药制剂教育部重点实验室开放基金（TCM-201904） |
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| 摘 要： | 目的 从肠道菌群角度,评价两亲性嵌段共聚物用于中药汤剂抑苦的适宜性和安全性.方法 以苦味强烈的盐酸小檗碱(berberinehydrochloride,BH)溶液为模型药物,采用高通量测序技术,对比研究两亲性嵌段共聚物、天然甜味剂(蔗糖)与人工甜味剂(阿斯巴甜)连续给药2周后对大鼠肠道菌群的影响.结果 BH经过两亲性嵌...
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| 关 键 词： | 中药汤剂 抑苦 两亲性嵌段聚合物 肠道菌群 汤剂伴侣开发 小檗碱 |
| 收稿时间： | 2020/8/28 0:00:00 |
Study on suitability of amphiphilic block copolymer for bitterness inhibition of traditional Chinese medicine decoction based on intestinal flora |
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| LIN Jun-zhi,LI Pan,QIU Min,KE Xiu-mei,HAN Li,YANG Ming,WU Zhen-feng,ZHANG Ding-kun.Study on suitability of amphiphilic block copolymer for bitterness inhibition of traditional Chinese medicine decoction based on intestinal flora[J].Chinese Traditional and Herbal Drugs,2021,52(1):65-74. |
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| Authors: | LIN Jun-zhi LI Pan QIU Min KE Xiu-mei HAN Li YANG Ming WU Zhen-feng ZHANG Ding-kun |
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| Institution: | Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China;Chengdu Qingbaijiang District People''s Hospital, Chengdu 610300, China;Pharmacy School, State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, China;Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China |
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| Abstract: | Objective To evaluate the suitability and safety of amphiphilic block copolymers for bitter suppression of traditional Chinese medicine decoction based on intestinal flora. Method Berberine hydrochloride (BH) with strong bitterness was used as model drug, the effects of amphiphilic block copolymer, natural sweetener (sucrose) and artificial sweetener (aspartame) on intestinal microflora of rats were compared after 2 weeks of continuous administration by high throughput sequencing technology. Result After being masked by amphiphilic block copolymers, sucrose and aspartame, the total number of species of BH was increased. The results showed that amphiphilic block copolymers did not affect the diversity and community composition of BH. Sucrose had a tendency to increase the diversity of BH flora, while aspartame had a tendency to decrease it. Conclusion Amphiphilic block copolymers do not interfere with the effect of the drug on intestinal flora in long-term medication, so it is a safe taste masking agent for children. |
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| Keywords: | traditional Chinese medicine decoction bitter-masking amphiphilic block copolymer intestinal flora development of decoction companion berberine |
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