益精补阳还五汤联合马来酸噻吗洛尔治疗POAG的疗效分析

目的:探讨益精补阳还五汤联合马来酸噻吗洛尔滴眼液对原发性开角型青光眼(POAG)患者眼血供、眼压及视力的影响。方法:选取2018-02/2020-02本院POAG患者120例,依据随机表分为滴眼组(60例,给予马来酸噻吗洛尔滴眼液治疗)和汤液组(60例,给予马来酸噻吗洛尔滴眼液联合益精补阳还五汤治疗),比较两组眼血供[视网膜中央动脉(CRA)和睫状后动脉(PCA)的舒张末期血流速度(EDV)、收缩期峰值血流速度(PSA)、阻力指数(RI)]、眼压、视力、视野[平均视敏度(MS)、平均视野缺损(MD)]、疗效、不良反应。结果:汤液组和滴眼组治疗后CRA和PCA的EDV、PSA及视力、MS明显高于治疗前,汤液组和滴眼组治疗后CRA、PCA的RI及眼压、MD明显低于治疗前,汤液组治疗后CRA和PCA的EDV、PSA及视力、MS明显高于滴眼组,汤液组治疗后CRA、PCA的RI及眼压、MD明显低于滴眼组(P<0.05);汤液组治疗有效率明显高于滴眼组(P<0.05);汤液组和滴眼组不良反应率无差异(P>0.05)。结论:益精补阳还五汤联合马来酸噻吗洛尔滴眼液可有效改善POAG患者眼血供、眼压及视力、视野,提高了疗效,且安全性好。

The Yijing Buyang Huanwu Decoction combined with timolol maleate in the treatment of POAG

AIM:To discuss the effect of Yijing Buyang Huanwu Decoction combined with timolol maleate eye drop on the blood supply and intraocular pressure in patients with primary open angle glaucoma(POAG).METHODS:The 120 patients with POAG in our hospital from February 2018 to February 2020 were selected,they were divided into decoction group(n=60)and eye drop group(n=60)according to the randomly table.The eye drop group was treated with timolol maleate eye drop,and the decoction group was treated with Yijing Buyang Huanwu Decoction on the basis of the eye drop group,the eye blood supply[end diastolic velocity(EDV),peak systolic velocity(PSA),resistance index(RI)of central retinal artery(CRA)and posterior ciliary artery(PCA)],intraocular pressure,visual acuity,visual field[mean sensitivity(MS),mean deviation(MD)],efficacy and adverse reactions were compared between the two groups.RESULTS:The EDV and PSA of the CRA and PCA and the visual acuity,MS in the Decoction group and eye drop group after treatment were significantly higher than those in the before treatment,the RI of the CRA and PCA and the intraocular pressure,MD in the Decoction group and eye drop group after treatment were significantly lower than those in the before treatment,the EDV and PSA of the CRA and PCA and the visual acuity,MS in the Decoction group after treatment were significantly higher than those in the eye drop group,the RI of the CRA and PCA and the intraocular pressure,MD in the Decoction group after treatment were significantly lower than those in the eye drop group(P<0.05).The effective rate in the Decoction group was significantly higher than that in eye drop group(P<0.05).There was no significant difference in adverse reactions between the Decoction group and eye drop group(P>0.05).CONCLUSION:Yijing Buyang Huanwu Decoction combined with timolol maleate eye drop can effectively improve the blood supply,intraocular pressure and visual acuity,visual field of patients with POAG,it can improve the efficacy,and it has the good safety,it’s worth for further clinical promotion.