| 网络药理学在中药研究中的应用进展 |
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| 引用本文： | 庄延双,蔡宝昌,张自力. 网络药理学在中药研究中的应用进展[J]. 南京中医药大学学报, 2021, 37(1): 156-160. DOI: 10.14148/j.issn.1672-0482.2021.0156 |
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| 作者姓名： | 庄延双 蔡宝昌 张自力 |
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| 作者单位： | 南京中医药大学泰州附属医院,江苏 泰州 225300;南京中医药大学药学院,江苏 南京 210023;南京中医药大学药学院,江苏 南京 210023 |
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| 基金项目： | 国家自然科学基金(82000572)。 |
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| 摘 要： | 中药具有多成分、多靶点和整体作用的特点,网络药理学具有与中药作用类似的特点,选择网络药理学技术来研究中药的药效物质基础和作用分子机制成为一种趋势.网络药理学技术可以帮助研究人员聚焦所需要研究的蛋白、基因和通路,成为研究人员常用的筛选工具.主要介绍了网络药理学常用研究方法,常用数据库和工具,对网络药理学在中药药效物质基础...
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| 关 键 词： | 网络药理学 物质基础 药性理论 毒性 中药 |
| 收稿时间： | 2020-03-09 |
Application Progress of Network Pharmacology in Traditional Chinese Medicine Research |
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| ZHUANG Yan-shuang,CAI Bao-chang,ZHANG Zi-li. Application Progress of Network Pharmacology in Traditional Chinese Medicine Research[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2021, 37(1): 156-160. DOI: 10.14148/j.issn.1672-0482.2021.0156 |
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| Authors: | ZHUANG Yan-shuang CAI Bao-chang ZHANG Zi-li |
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| Affiliation: | 1.Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou, 225300, China2.School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China |
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| Abstract: | Traditional Chinese medicine(TCM)has the characteristics of multi-component,multi-target and overall action.Network pharmacology has similar characteristics with TCM.Therefore,it is a trend to choose network pharmacology technology to study the material foundation and molecular mechanism of TCM.Network pharmacology technology can help researchers focus on the proteins,genes,and pathways,and become a common screening tool for researchers to conduct research.This paper mainly introduces the common research methods,commonly used databases and tools of network pharmacology,summarizes the material foundation and molecular mechanism of TCM,the properties theory,the toxic mechanism of TCM,the challenges and prospects of network pharmacology in the application of TCM,in order to provide a certain reference for the subsequent research of network pharmacology in TCM. |
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| Keywords: | network pharmacology material foundation properties theory toxicity traditional Chinese medicine |
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