云香十五味丸联合塞来昔布胶囊治疗膝骨关节炎的疗效观察

目的 研究云香十五味丸联合塞来昔布胶囊对膝骨关节炎患者的临床疗效。方法 选择2018年1月—2019年6月就诊于鄂尔多斯市中心医院的200例膝骨关节炎患者作为研究对象。对照组口服塞来昔布胶囊，0.2 g/次，1次/d。观察组在对照组基础上临睡前口服云香十五味丸，10粒/次，1次/d。两组均治疗3个月。治疗2周、1个月、3个月后，两组患者VAS积分均明显降低（P<0.05）。治疗1个月后，治疗组患者的VAS评分明显低于对照组（P<0.05）。治疗后，两组患者不同时间疼痛程度、僵硬程度、生活困难程度积分及WOMAC总积分均明显降低（P<0.05）。治疗2周，观察组患者晨起僵硬及WOMAC总积分明显低于对照组；治疗1个月，观察组各项目积分及WOMAC总积分均明显低于对照组（P<0.05）。治疗3个月，TESS评分变化较小，差异不具有统计学意义。结论 云香十五味丸联合塞来昔布胶囊能有效减轻膝骨关节炎患者疼痛，改善关节功能，具有一定的的临床推广价值。

Effect observation on Yunxiang Shiwu Pills combined with Celecoxib Capsules in treatment of knee osteoarthritis

Objective To study the clinical effectiveness of Yunxiang Shiwu Pills combined with Celecoxib Capsules in treatment of knee osteoarthritis. Methods A total of 200 patients with knee osteoarthritis who visited Ordos Central Hospital from January 2018 to June 2019 were selected as the study subjects. Patients in the control group were po administered with Celecoxib Capsules, 0.2 g/time, once daily. Patients in the observation group were po administered Yunxiang Shiwu Pills on the basis of control group, 10 pills/time, once daily. Both groups were treated for 3 months. After treatment, the changes of VAS, WOMAC, and TESS between two groups of patients before and, 2 weeks, 1 month, and 3 months after treatment were compared. Results After 2 weeks, 1 month and 3 months of treatment, VAS scores of patients in two groups were significantly reduced (P<0.05). After 1 month of treatment, VAS score of patients in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the pain degree, stiffness degree, life difficulty score, and WOMAC total score of two groups were significantly reduced at different times (P<0.05). Two weeks after treatment, morning stiffness and WOMAC score in the observation group were significantly lower than those in the control group. One month after treatment, the scores of each item and WOMAC in the observation group were significantly lower than those in the control group (P<0.05). TESS score changed little after 3 months of treatment, and the difference was not statistically significant. Conclusion Yunxiang Shiwu Pills combined with Celecoxib Capsules can effectively alleviate the pain and improve the joint function of patients with knee osteoarthritis, which has certain clinical promotion value.