高频rTMS、脑仿生电及其序贯治疗脑外伤持续植物状态患者的临床观察

目的:观察高频重复经颅磁刺激(rTMS)、脑仿生电刺激及其序贯治疗脑外伤持续植物状态(PVS)患者的临床疗效.方法:入组的脑外伤PVS患者予常规药物及康复治疗,并随机分为3组:rTMS组(24例),予高频rT-MS治疗;脑仿生电组(23例),予脑仿生电治疗;rTMS与脑仿生电联合组(简称联合组,26例),先高频rTMS...

Clinical observation of high-frequency rTMS and biomimetic electroencephalography in the sequential treatment of patients with persistent vegetative state of brain injury

Objective: To investigate the clinical effect and mechanism of the sequential treatment of high-frequency repetitive transcranial magnetic stimulation (rTMS) and brain biomimetic electrical stimulation for the patients with persistent vegetative state (PVS) after brain injury. Methods: Patients with PVS after brain injury were given conventional treatment and randomly divided into three groups: rTMS group (24 cases) was treated by high frequency rTMS; brain biomimetic electrical stimulation group (23 cases) was treated by brain biomimetic electrical stimulation; the combined group (26 cases) was given rTMS combined with brain biomimetic electrical stimulation sequentially. Before and after 6 weeks of treatment, the CRS-R efficacy rating scale was used to evaluate the consciousness of all the patients; the changes of EEG, brainstem auditory evoked potential (BAEP) and somatosensory evoked potential (SEP) were recorded and compared. Results: After treatment of 4 weeks, CRS R scores, the EEG, BEAP and SEP levels in the three groups were improved significantly (P<0.05), more significantly in the combined group than in the brain biomimetic electrical stimulation group or rTMS group (P<0.05). All waves of BEAP, SEP in the three groups were decreased significantly (P<0.05), more significantly in the combined group than in the brain biomimetic electrical stimulation group or rTMS group (P<0.05).Conclusion: High-frequency rTMS or brain biomimetic electrical stimulation can improve the consciousness and brain electrophysiology of PVS patients after brain injury, and the sequential treatment was significantly superior to the single treatment.