| Flavonoids in myocardial ischemia–reperfusion injury: Therapeutic effects and mechanisms |
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| 作者姓名： | Jun-ying Jia Er-huan Zang Li-juan Lv Qin-yu Li Chun-hua Zhang Ying Xia Lei Zhange Lian-sheng Dangf Min-hui Li e |
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| 作者单位： | a College of Agriculture, Inner Mongolia University for Nationalities, Tongliao 028000, China;b Baotou Medical College, Baotou 014040, China;c Department of Basic Science, Tianjin Agricultural University, Tianjin 300384, China;d Inner Mongolia Institute of Traditional Chinese Medicine, Hohhot 010020, China;e Inner Mongolia Medical University, Hohhot 010110, China;f Department of Geriatrics, The First Affiliated Hospital of Baotou Medical College, Baotou 014000, China;b Baotou Medical College, Baotou 014040, China
d Inner Mongolia Institute of Traditional Chinese Medicine, Hohhot 010020, China
e Inner Mongolia Medical University, Hohhot 010110, China
g Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources and Utilization, Baotou Medical College, Baotou 014040, China |
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| 基金项目： | financial supports from the National Natural Science Foundation of China (No. 81874336, 81303306);Tianjin Applied Basic and Frontier Technology Research Plan (15JCQNJC13400);The National Natural Science Foundation of Inner Mongolia (2018ZD13)。 |
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| 摘 要： | Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties;They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI). In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e)myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.
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| 关 键 词： | ANTI-APOPTOSIS ANTI-INFLAMMATION antioxidant activity FLAVONOIDS myocardial ischemia-reperfusion injury |
| 收稿时间： | 12 March 2020 |
Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms |
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| Jun-ying Jia,Er-huan Zang,Li-juan Lv,Qin-yu Li,Chun-hua Zhang,Ying Xia,Lei Zhange,Lian-sheng Dangf,Min-hui Li,e.Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms[J].Chinese Herbal Medicines,2021,13(1):49-63. |
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| Authors: | Jun-ying Jia Er-huan Zang Li-juan Lv Qin-yu Li Chun-hua Zhang Ying Xia Lei Zhange Lian-sheng Dangf Min-hui Li e |
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| Institution: | 1. College of Agriculture, Inner Mongolia University for Nationalities, Tongliao 028000, China;2. Baotou Medical College, Baotou 014040, China;3. Department of Basic Science, Tianjin Agricultural University, Tianjin 300384, China;4. Inner Mongolia Institute of Traditional Chinese Medicine, Hohhot 010020, China;5. Inner Mongolia Medical University, Hohhot 010110, China;6. Department of Geriatrics, The First Affiliated Hospital of Baotou Medical College, Baotou 014000, China;7. Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources and Utilization, Baotou Medical College, Baotou 014040, China |
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| Abstract: | Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients' quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties; They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI). In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e)myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI. |
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| Keywords: | anti-apoptosis anti-inflammation antioxidant activity flavonoids myocardial ischemia-reperfusion injury |
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