人参根和根茎中新的聚乙炔类化学成分

目的 研究人参Panaxginseng根和根茎的聚乙炔类化学成分.方法 采用硅胶、反相HPLC等柱色谱方法进行分离纯化,通过红外、紫外、质谱、核磁共振等谱学数据鉴定化合物的结构.结果 从人参根和根茎的95％乙醇水提取物中分离得到17个聚乙炔类化合物,分别鉴定为人参炔K(1)、人参炔醇(2)、(9Z)-1-甲氧基-9-十...

New polyacetylenes from roots and rhizomes of Panax ginseng

Objective To study polyacetylenes in the roots and rhizomes of Panax ginseng. Methods Polyacetylenes were separated and purified by repeated column chromatographies on normal and reversed phase silica gels, respectively. Their chemical structures were determined by spectral data analyses of IR, UV, MS and NMR. Results Seventeen compounds were isolated from 95% ethanolic alcohol aqueous extract of the roots and rhizomes of P. ginseng and identified as ginsenoyne K (1), panaxynol (2), (9Z)-1-methoxy-9-heptadecaen-4,6-diyne-3-one (3), panaxjapyne A (4), (3R,9R,10R)-panaxytriol (5), 10-methoxyheptadeca-1,16-diene-4,6-diyne-3,9-diol (6), ginsenoyne A (7), 10-methoxyheptadeca-1-ene-4,6-diyne-3,9-diol (8), panaquinquecol 7 (9), 9,10-epoxy-16-heptadecaene-4,6-diyn-3-ol (10), panaxydol (11), ginsenoyne D (12), panaquinquecol 4 (13), 1-methoxy-(9R,10S)-epoxyheptadecan-4,6-diyn-3-one (14), ginsenoyne E (15), panaxydiol (16) and panaxyne (17), respectively. Conclusion Compounds 6 and 10 are the new ones, which were given the trivial name as panaxytriol methyl ether and panaxenydol, respectively. Compounds 4, 9 and 13 are isolated from the roots and rhizomes of P. ginseng for the first time.