| 细胞毒性T淋巴细胞相关抗原-4的生物学功能及其在头颈部鳞状细胞癌治疗中的应用 |
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| 引用本文： | 胡晨,张明. 细胞毒性T淋巴细胞相关抗原-4的生物学功能及其在头颈部鳞状细胞癌治疗中的应用[J]. 中国眼耳鼻喉科杂志, 2001, 19(5): 363-365. DOI: 10.14166/j.issn.1671-2420.2019.05.019 |
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| 作者姓名： | 胡晨 张明 |
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| 作者单位： | 复旦大学附属眼耳鼻喉科医院耳鼻喉科 上海 200031 |
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| 摘 要： | 细胞毒性T淋巴细胞(T细胞)相关抗原-4(CTLA-4)是一种白细胞分化抗原,是T细胞上的一种跨膜受体,与CD28竞争性结合B7分子配体。CTLA-4与B7分子结合后发生T细胞无反应性,参与免疫反应负调节,与头颈部鳞状细胞癌的免疫逃逸密切相关。本文就CTLA-4的基本结构、功能与抗CTLA-4免疫疗法在头颈鳞状细胞癌中的应用做一综述。
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| 关 键 词： | 细胞毒性T淋巴细胞相关抗原-4 头颈部鳞状细胞癌 免疫治疗 联合治疗 |
| 收稿时间： | 2018-10-15 |
Cytotoxic T lymphocyte-associated antigen-4 and its application in the therapy of the head and neck squamous cell carcinomas |
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| HU Chen,ZHANG Ming. Cytotoxic T lymphocyte-associated antigen-4 and its application in the therapy of the head and neck squamous cell carcinomas[J]. Chinese Journal of Ophthalmology and otorhinolaryngology, 2001, 19(5): 363-365. DOI: 10.14166/j.issn.1671-2420.2019.05.019 |
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| Authors: | HU Chen ZHANG Ming |
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| Abstract: | Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4),which is a kind of leukocyte differentiation antigen and a kind of transmembrane receptors of T cells, enjoys together with CD28 B7 molecule ligands. The combining of CTLA-4 with B7 molecules could reduce T cell reactivity. It participates in the negative regulation of immune response and is related to the immune escape of the head and neck squamous cell carcinoma. In this review, the fundamental structure and functions of CTLA-4, and anti-CTLA-4 immune therapy in the head and neck squamous cell carcinoma were summarized. |
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| Keywords: | Cytotoxic T lymphocyte-associated antigen- 4 Head and neck squamous cell carcinomas Immune therapy Combined treatment |
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