泽漆化学成分研究

目的研究泽漆Euphorbia helioscopia的化学成分。方法采用硅胶柱色谱、Sephadex LH-20柱色谱及制备液相色谱等方法进行分离纯化,并经理化性质与光谱数据鉴定化合物结构。结果从泽漆70%乙醇提取物中分离得到23个化合物,依次鉴定为β-谷甾醇(1)、euphoscopin B(2)、对羟基苯乙酮(3)、euphoscopin F(4)、euphoscopin C(5)、nepehinol(6)、4-羟基-3,5-二甲氧基苯甲醛(7)、antiquorin(8)、1H-吲哚-3-甲醛(9)、7-羟基-6-甲氧基香豆素(10)、泽漆内酯A(11)、euphoheliosnoid A(12)、松脂素(13)、(+)-去氢催吐萝芙木醇(14)、loliolide(15)、1-(4-羟基-3-甲氧基苯基)-3-羟基丙-1-酮(16)、3-羟基乙酰吲哚(17)、橙皮酰胺(18)、rayalinol(19)、3-O-β-D-吡喃葡萄糖基泽漆内酯A(20)、柚皮素(21)、4′,5,7-三羟基异黄酮(22)、槲皮素(23)。结论化合物10、17、19、20、22为首次从大戟属植物中分离得到,化合物3、7~9、14~16、18为首次从该植物中分离得到。

Chemical constituents of Euphorbia helioscopia

Objective To study the chemical constituents of Euphorbia helioscopia.Methods The compounds were isolated and purified by silica gel,SephadexLH-20 column chromatography and preparative HPLC,and their structures were identified by analysis of physicochemical properties and spectroscopic evidences.Results Twenty-three compounds were isolated from the 70%EtOH extract of E.helioscopia.Their structures were identified asβ-sitosterol(1),euphoscopin B(2),4-hydroxyacetophenone(3),euphoscopin F(4),euphoscopin C(5),nepehinol(6),4-hydroxy-3,5-dimethoxybenzaldehyde(7),antiquorin(8),1H-indole-3-carboxaldehyde(9),7-hydroxy-6-methoxycoumarin(10),helioscopinolide A(11),euphoheliosnoid A(12),pinoresinol(13),(+)-dehydrovomifoliol(14),loliolide(15),1-(4-hydroxy-3-methoxy-phenyl)-3-hydroxypropan-1-one(16),3-(hydroxyacetyl)indole(17),aurantiamide(18),rayalinol(19),3-O-β-D-glucopyranosylhelioscopinolide A(20),naringenin(21),4′,5,7-trihydroxyisoflavones(22)and quercetin(23).Conclusion Compounds 10,17,19,20,22 are isolated from Euphorbia genus for the first time,3,7—9,14—16,18 are isolated from E.helioscopia for the first time.