| 肿瘤硼中子俘获治疗的理论基础与近期研究进展 |
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| 引用本文： | 徐笛,张玉财,周琪怡,赵利.肿瘤硼中子俘获治疗的理论基础与近期研究进展[J].中华放射医学与防护杂志,2021,41(1):74-77. |
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| 作者姓名： | 徐笛 张玉财 周琪怡 赵利 |
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| 作者单位： | 苏州大学放射医学与防护学院 江苏省高校放射医学协同创新中心 放射医学与辐射防护国家重点实验室, 苏州 215123 |
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| 基金项目： | 国家自然科学基金（31600805）；江苏省自然科学基金（BK20160329） |
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| 摘 要： | 硼中子俘获治疗(BNCT)是一种新型肿瘤精准治疗方法 ,通过肿瘤细胞内的10B俘获热中子发生核裂变反应产生a粒子和反冲7Li核选择性地杀死肿瘤细胞.将足量的10B选择性递送到肿瘤细胞内部是BNCT成功的关键.本文简要介绍了BNCT治疗肿瘤的理论基础,综述了BNCT所用的中子源和硼递送剂的近期研究进展,简述了BNCT临床...
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| 关 键 词： | 硼中子俘获治疗 中子源 硼递送剂 肿瘤 |
| 收稿时间： | 2020/10/15 0:00:00 |
Boron neutron capture therapy of cancers: principles and recent research progress |
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| Xu Di,Zhang Yucai,Zhou Qiyi,Zhao Li.Boron neutron capture therapy of cancers: principles and recent research progress[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):74-77. |
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| Authors: | Xu Di Zhang Yucai Zhou Qiyi Zhao Li |
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| Institution: | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China |
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| Abstract: | Boron neutron capture therapy(BNCT)is a new method for the precise treatment of cancers.By this method,cancer cells can be selectively killed byαparticles and recoiling 7Li nuclei generated by the nuclear fission reaction occurring when the 10B isotope atoms in cancer cells capture thermal neutrons.The key to a successful BNCT is to deliver sufficient 10B into the cancer cells.The purpose of this review is to introduce the principles of BNCT and review recent progress in the development of neutron sources and boron delivery agents,as well as the result of BNCT clinical trials. |
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| Keywords: | Boron neutron capture therapy Neutron sources Boron delivery agents Cancer |
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