泰素帝对荷瘤小鼠肿瘤组织VEGF和TSP1表达的影响 |
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引用本文: | 钱晓萍,马亚军,刘宝瑞.泰素帝对荷瘤小鼠肿瘤组织VEGF和TSP1表达的影响[J].陕西肿瘤医学,2009,17(9):1650-1653. |
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作者姓名: | 钱晓萍 马亚军 刘宝瑞 |
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作者单位: | 南京大学医学院附属鼓楼医院肿瘤中心,江苏南京210008 |
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基金项目: | 江苏省自然科学基金(BK2006005) |
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摘 要: | 目的:观察泰素帝对裸鼠人大肠癌LOVO细胞皮下移植瘤血管生成抑制作用及其作用机理。方法:通过建立裸鼠人大肠癌LOVO细胞皮下移植瘤模型,观察泰素帝的抑瘤作用,并采用免疫组织化学法检测泰素帝对肿瘤组织MVD、VEGF、TSP1表达的影响。结果:泰素帝的抑瘤率为72.4%。泰素帝能显著降低肿瘤微血管密度,下调VEGF和上调TSP1的表达。结论:泰素帝可能通过抑制肿瘤血管生成而发挥抗肿瘤作用;下调VEGF可能是泰素帝抗血管生成作用机理之一;上调TSP1可能是泰素帝抗血管生成另一作用机理。
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关 键 词: | 血管生成 肿瘤 泰素帝 微血管密度 血管内皮生长促进因子 凝血酶敏感蛋白-1 |
Effects of docetaxel on the expression of VEGF and TSP1 on transplanted human carcinoma in nude mice |
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Institution: | QIAN Xiao - ping, MA Ya - jun, LIU Bao - rui (Department of Oncology,Affiliated Drum Tower Hospital,Medical School of Nanfing University, Clinical Cancer Institute of Nanjing University, Nanfing Jiangsu 210008, China.) |
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Abstract: | Objective:To observe the effect of docetaxel on transplanted human carcinoma of colon LOVO ceils in nude mice. Methods:The tumor model was established by injecting human carcinoma of colon LOVO ceils under the nude mice armpit skin of its right forearm. To observe the tumor - inhibitory rate of docetaxel and the expressions of MVD,VEGF and TSP1 in tumor tissue by means of immunohistochemistry. Results:Tumor- inhibitory rate of docetaxel was 72.4%. It can suppress significantly the expression of MVD, VEGF,while raise the expression of TSP1.Conclusion:Docetaxel could inhibit the angiogenesis of tumor. Docetaxel could reduce the expression of VEGF. And raise the expression of TSP1. |
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Keywords: | angiogenesis tumor docetaxel MVD VEGF TSP - 1 |
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