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| 肾移植术后普通环孢素A与环孢素A微乳剂对移植肾功能影响的系统评价 | |
| 引用本文： | 李旭东,杨宇如,王莉,吴泰相. 肾移植术后普通环孢素A与环孢素A微乳剂对移植肾功能影响的系统评价[J]. 现代泌尿外科杂志, 2007, 12(5): 295-297 |
| 作者姓名： | 李旭东 杨宇如 王莉 吴泰相 |
| 作者单位： | 1. 西安交通大学第一医院泌尿外科,陕西西安,710061 2. 四川大学华西医院泌尿外科,四川成都,610041 3. 中国循证医学中心,四川成都,610041 |
| 摘 要： | 目的评价肾移植术后普通环孢素A与环孢素A微乳剂对受者移植肾功能影响的差异。方法遵循Cochrane肾脏协作组随机对照试验检索策略，检索MEDLINE（1994—2006．3）、EMBASE（1994～2006．3）、中国生物医学文献数据库CBM（1994—2006．3）、Cochrane图书馆（2005年第4期）与肾移植相关的8种中文杂志。采用Revman4．2．7进行Meta分析。结果共有5个随机对照试验纳入研究，包括1671例同种异体尸体肾移植患者。结论肾移植术后使用普通环孢素A与环孢素A微乳剂相比受者移植肾功能无明显差异，但环孢素A微乳剂肾毒性发生率较高。 |
| 关 键 词： | 肾移植 环孢素A 剂型 肾功能 Mate分析 |
| 文章编号： | 1009-8291（2007）05-0295-03 |
| 修稿时间： | 2006-10-12 |
Efficacy of microemulsion and conventional formulations of cyclosporine A on renal function after renal transplantation |
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| Li Xudong,Yang Yuru,Wang Li,Wu Taixiang. Efficacy of microemulsion and conventional formulations of cyclosporine A on renal function after renal transplantation[J]. Journal of MOdern Urology, 2007, 12(5): 295-297 | |
| Authors: | Li Xudong Yang Yuru Wang Li Wu Taixiang |
| Affiliation: | Li Xudong , Yang Yuru , Wang Li , Wu Taixiang (1. Department of Urology, The First Hospital of Xi＇an Jiaotong University, Xi＇an 710061; 2. Department of Urology, West China Hospital, Sichuan University, Chengdu 610041; 3. Chinese Evidence-Based Medicine Center, Chengdu 610041, China) |
| Abstract: | Objective To evaluate the efficacy of microemulsion and conventional formulations of cyclosporine A on renal function after renal transplantation. Methods Following the search strategy developed for the Cochrane Renal Group specialized register of randomized controlled trials, we searched MEDLINE (1994-2006.3); EMBASE (1994-2006.3), the Chinese Biomedical Database (CBM) (1994-2006.3), Cochrane Central Register of Controlled Trials (The Cochrane Library, 4th issue of 2005), and 8 types of Chinese journals. We then applied Revman 4.2.7 for meta-analysis. Results 5 studies involving 1671 patients were included. Conclusion There was no significant difference on the level of serum creatinine between the two formulations, but microemulsive cyclosporine A had a higher incidence of nephrotoxicosis. |
| Keywords: | renal transplantation cyclosporine A formulation renal function Meta-analyses |
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