The Regulatory Effect of Histamine on the in Vitro Synthesis of IgE |
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| Authors: | Y. Levo R. J. Harbeck C. H. Kirkpatrick |
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| Affiliation: | Department of Medicine "T", Ichilov Hospital, Tel Aviv, Israel;the Division of Clinical Immunology, Department of Medicine, National Jewish Hospital, Denver, U.S.A. |
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| Abstract: | The effect of histamine and its H1 and H2 antagonists, chlorpheniramine and cimetidine, on the in vitro, PWM-induced, synthesis of IgG and IgE was studied. Histamine had no effect, and cimetidine had a slight inhibitory action. In contrast, chlorpheniramine induced marked suppression of both IgE and IgG synthesis. This effect could not be attributed to drug-induced cytotoxicity. These results suggest that the modulatory effect of histamine on antibody production involves predominantly H1 receptors. |
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| Keywords: | histamine histamine-antagonists IgE synthesis |
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