Significance of pepsinogen in screening for gastric intestinal metaplasia in Guangdong,China |
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Authors: | Xujuan Liu Min Zhang Riyu Luo Keran Mo Xingxiang He |
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Institution: | 1.Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China; 2.Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China; 3.School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China |
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Abstract: | ObjectiveDiagnosis of gastric intestinal metaplasia (GIM) relies on gastroscopy and histopathologic biopsy, but their application in screening for GIM is limited. We aimed to identify serological biomarkers of GIM via screening in Guangdong, China.MethodsCross-sectional field and questionnaire data, demographic information, past medical history, and other relevant data were collected. Blood samples were collected for pepsinogen (PG)I, PGII, gastrin-17, and Helicobacter pylori antibody testing, and gastroscopy and histopathologic biopsy were performed. Single factor and logistic regression analyses were used to evaluate the correlation between these indicators and GIM, and decision tree models were used to determine the cut-off points between indicators.ResultsOf 443 participants enrolled, 87 (19.6%) were diagnosed with GIM. Single factor analysis showed that pepsin indicators (PGI, PGII, and PGI/PGII ratio) and the factors Mandarin as native language, urban residency, hyperlipidemia, and age were associated with GIM. Logistic regression analysis showed that PGI and age were associated with GIM.ConclusionsAge is an important factor for predicting GIM progression; age >60 years increased its risk. Detection of GIM was higher in individuals with PGI levels >127.20 ng/mL, which could be used as a threshold indicating the need to perform gastroscopy and histopathologic biopsy. |
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Keywords: | Pepsinogen gastric intestinal metaplasia screening gastric cancer screening gastroscopy PGI/PGII ratio logistic regression |
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