Toxicological evaluation of Yulangsan polysaccharide in Wistar rats: A 26-week oral gavage study |
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| Affiliation: | 1. Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;2. Razi Drug Research Center, Department of pharmacology, Iran University of Medical Sciences, Tehran, Iran;3. Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran;4. Department of Pediatrics, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran;1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China;2. State Key Laboratory of Natural Medicines and Department of Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China |
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| Abstract: | Although numerous studies have proven the medicinal values of Yulangsan polysaccharide (YLSP), the toxicity of this active ingredient is unknown. In the acute toxicity study, a single oral administration of 24 g/kg YLSP caused neither toxicological symptoms nor mortality, and the LD50 was estimated >24 g/kg. In the chronic toxicity study, we administered doses of 0, 0.6, 1.2 and 2.4 g/kg YLSP in rats by oral gavage for 26 weeks followed by a 3-week recovery period. There was no mortality or remarkable clinical signs observed during this 26-week study. Additionally, there were no toxic differences in the following parameters: body weight, food consumption, hematology, clinical biochemistry, organ weight, and macroscopic findings. There were no adverse effects on histopathology observed in males or female rats treated with YLSP. Based on the results, the no-observed-adverse-effect-level of YLSP in rats is greater than 2.4 g/kg when administered orally for 26 consecutive weeks. |
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| Keywords: | Yulangsan polysaccharide Toxicological evaluation Wistar rats |
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