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TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma |
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| Authors: | Kiyokazu Shirai Genta Nagae Motoaki Seki Yotaro Kudo Asuka Kamio Akimasa Hayashi Atsushi Okabe Satoshi Ota Shuichi Tsutsumi Takanori Fujita Shogo Yamamoto Ryo Nakaki Yasuharu Kanki Tsuyoshi Osawa Yutaka Midorikawa Keisuke Tateishi Masao Ichinose Hiroyuki Aburatani |
| Institution: | 1. Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
Department of Gastroenterology, Wakayama Medical University, Wakayama, Japan;2. Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan;3. Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan;4. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;5. Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan Laboratory of Genetics, Department of Biological Sciences, The University of Tokyo, Tokyo, Japan;6. Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan Department of Pathology, Kyorin University Faculty of Medicine, Mitaka, Japan;7. Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;8. Division of Integrative Nutriomics and Oncology, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan;9. Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan;10. Department of Gastroenterology, Wakayama Medical University, Wakayama, Japan Faculty of Medicine, Teikyo University, Tokyo, Japan |
| Abstract: | |
| Keywords: | enhancer epigenome profiling hepatocellular carcinoma hydroxymethylation TET1 |