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Bedaquiline as Treatment for Disseminated Nontuberculous Mycobacteria Infection in 2 Patients Co-Infected with HIV |
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| Authors: | Eliza Gil Nicola Sweeney Veronica Barrett Stephen Morris-Jones Robert F. Miller Victoria J. Johnston Michael Brown |
| Affiliation: | University College London Hospitals, National Health Service Foundation Trust, London, UK (E. Gil, N. Sweeney, V. Barrett, S. Morris-Jones, V.J. Johnston, M. Brown);Central and North West London National Health Service Foundation Trust, London (R.F. Miller);University College London, London (R.F. Miller);London School of Hygiene and Tropical Medicine, London (R.F. Miller, V.J. Johnston, M. Brown) |
| Abstract: | Nontuberculous mycobacteria can cause disseminated infections in immunocompromised patients and are challenging to treat because of antimicrobial resistance and adverse effects of prolonged multidrug treatment. We report successful treatment with bedaquiline, a novel antimycobacterial drug, as part of combination therapy for 2 patients with disseminated nontuberculous mycobacteria co-infected with HIV. |
| Keywords: | bedaquiline antibacterial drugs antitubercular drugs antiinfective drugs antitubercular drugs Mycobacteriaceae Mycobacterium Mycobacterium abscessus Mycobacterium avium nontuberculous mycobacteria NTM bacteria tuberculosis and other mycobacteria HIV viruses co-infection antimicrobial resistance respiratory infections 18fluorodeoxyglucose-positron emission tomography/computed tomography imaging |