| 药物临床试验计算机仿真简介 |
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| 引用本文： | 郑丹,朱玲,施心陵,张榆峰. 药物临床试验计算机仿真简介[J]. 中国临床药理学与治疗学, 2007, 12(6): 705-709 |
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| 作者姓名： | 郑丹 朱玲 施心陵 张榆峰 |
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| 作者单位： | 云南大学信息学院电子工程系,昆明,650091,云南 |
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| 摘 要： | 本文综述了药物临床试验计算机仿真的发展、设计及应用。从药代动力学、药效动力学的角度介绍了药物临床试验计算机仿真,进而根据国外药物临床试验的计算机仿真情况分析了仿真设计的基本方法以及模型计算和软件,最后讨论了药物临床试验计算机仿真的研究应用。
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| 关 键 词： | 药物临床试验 计算机仿真 仿真模型 药代动力学 药效动力学 |
| 文章编号： | 1009-2501（2007）06-0705-05 |
| 修稿时间： | 2006-12-202007-04-13 |
Simulation of clinical trials: concepts and basic principles |
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| ZHENG Dan,ZHU Ling,SHI Xin-ling,ZHANG Yu-feng. Simulation of clinical trials: concepts and basic principles[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(6): 705-709 |
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| Authors: | ZHENG Dan ZHU Ling SHI Xin-ling ZHANG Yu-feng |
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| Affiliation: | Electronieal Engineering Department, Information School, Yurman University, Kunming 650091, Yunnan , China |
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| Abstract: | This paper reviewed the development, design and applications of clinical trial simulation (CTS). It introduced the clinical trial simulation from the view of the pharmacokinetics and pharmacodynamics. Then the general techniques, computer models and simulation software used for CTS were analyzed. Finally, some applications of clinical trial simulation were discussed. |
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| Keywords: | clinical trial computer simulation simulation model pharmacokinetics pharmacodynamics |
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