医院病原菌分布及耐药趋势分析

目的为临床医师合理使用抗生素提供参考依据,减少耐药菌株的产生。方法用回顾性调查的方法对我院近三年(2002-2004)临床送检标本中培养分离的2140株病原菌,从种类、对药物敏感性进行汇总及分析。结果革兰氏阴性杆菌(简称G-b)对亚胺培南、头孢吡肟和美洛培南敏感率较好,对环丙沙星、哌拉西林、红霉素敏感率稳定,其余14种抗生素敏感率呈下降趋势。革兰氏阳性球菌(简称G c)首选药为万古霉素。结论临床医师应根据药敏实验结果,正确、合理地使用抗生素。

Distribution and Trend of Drug Resistance of Hospital Pathogenic Bacteria

Objective To investigate the distribution and the trend of drug resistance of the hospital pathogenic bacteria,provide a guideline of rational use of antibiotic for the doctors and reduce the generation of drug resistant bacterial strains.Methods The distribution of 2 140 bacterial strains and antimicrobial susceptibility of these strains in the past three years(2002-2004)were analyzed retrospectively.Results Of 2 140 clinical isolates,Gram negative bacteria were highly susceptible to IMI(imipenem),FEP(cefepime)and MERO(meropenem),while the susceptibility to CIP(ciprofloxacin),PICP(penicillin)and E(erythromycin)were not changed.However,the susceptibilities to other 14 antibiotics were reduced.Gram positive bacteria were susceptible to VA(vancomycin).Conclusion Clinicians should apply antibiotics rationally in order to reduce the drug resistant bacterial strains.