| 狗肠系膜动静脉平滑肌的亚细胞膜酶活性和钙—累积功能之比较 |
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| 引用本文： | 关永源,施安国,关超然.狗肠系膜动静脉平滑肌的亚细胞膜酶活性和钙—累积功能之比较[J].中国药理学通报,1988(6). |
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| 作者姓名： | 关永源 施安国 关超然 |
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| 作者单位： | 中山医科大学药理教研组，南通医学院药理教研组，Smooth Muscle Research Program，Department of Neurosciences，McMaster University，Hamilton，Ontario，L8N 3Z5 Canada 广州访问学者，南通访问学者 |
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| 摘 要： | 从狗肠系膜动静脉平滑肌分离出不同部分亚细胞膜。其中微粒体部分(MIC)与浆膜F_2部分富含质膜成分,其膜标记酶活性分别为粗膜的4～5倍及10～12倍。酶活性在动静间存在组织差异。静脉MIC与F_2有较强Ca~(2+)结合和较弱的Ca~(2+)转运能力。
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| 关 键 词： | 肠系膜 动静脉 亚细胞膜 钙结合 钙转运 膜标记酶 |
A COMPARISON OF ENZYMATIC ACTIVITIES, Ca~(2+) BINDING AND Ca~(2+) TRANSPORT FUNCTIONS IN SUBCELLULAR MEMBRANE FRACTIONS ISOLATED FROM DOG MESENTERIC ARTERIES AND VEINS |
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| Guan Yongyuan,Shi Anguo & Kwan Chiuyin.A COMPARISON OF ENZYMATIC ACTIVITIES, Ca~(2+) BINDING AND Ca~(2+) TRANSPORT FUNCTIONS IN SUBCELLULAR MEMBRANE FRACTIONS ISOLATED FROM DOG MESENTERIC ARTERIES AND VEINS[J].Chinese Pharmacological Bulletin,1988(6). |
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| Authors: | Guan Yongyuan Shi Anguo & Kwan Chiuyin |
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| Abstract: | Using subcellular membrane fractions isolated from smooth muscles of dog mesenteric arteries and veins, we compared their enzymatic activities, Ca2+ bindind and Ca2+ transport. The micro-somal (MIC)and plasma membrane(F2) fractions were similarly enriched 4-5 and 10-12 fold respectively in the plasma membrane marker enzymes over the starting membrane mixture. However, MIC and F2 fractions from venous smooth muscle showed higher Mg2+-ATPase activity, slightly increased Ca2+ binding and reduced Ca2+-transport compared to the corresponding fractions from arteries. |
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| Keywords: | Mesenteric artery Vein Subcellular membrane Ca~(2+)-binding Ca~(2+) -transport Membrane marker enzyme |
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