复合材料制备可溶性微针及性能研究

目的 聚合物会影响微针的形态、机械性能和药物传输效率。考察不同聚合物对微针性能的影响,将聚合物复合以弥补单一材料制备微针的局限性。方法 以甲基乙烯基醚/马来酸酐共聚物(copolymers of methyl vinyl ether and maleic acid, PVM/MA)、甲基乙烯基醚/顺丁烯二酸酐共聚物(copolymers of methyl vinyl ether and maleic anhydride, PMVE/MAH)、 聚维酮(PVP) K29/32、PVP K90、聚乙烯醇(PVA)05-88和羟丙甲纤维素(HPMC)E5作为基质材料,采用多次离心法制备复合微针,以微针的形态、成针率、插入率和体外溶出作为评价指标,考察不同基质材料组合对微针性能的影响。结果 韧性材料PVA和HPMC分别与脆性材料PVM/MA、PMVE/MAH和PVP K29/32复合可以提高制备微针的各项性能;随着脆性材料占比增加,微针的形态和机械强度明显提升;聚合物种类和比例的变化还能改善微针的溶解速度。结论 韧性材料和脆性材料以适宜的比例复合能制备形态优良、机械强度高、皮肤附着力强的微针。

Preparation Study and Performance Evaluation of Dissolving Microneedles by Composite Materials

OBJECTIVE To study the performance of microneedle(MN) with different polymers to overcome the limitation of MN that was prepared by using single type of polymer. METHODS MNs was fabricated from PVM/MA,PMVE/MAH,PVP K29/32,PVP K90,PVA 05-88 and HPMC E5,using the centrifugal molding method.The needle formability, needle content,insertion ratio and dissolution rate were evaluated to compare the performance's difference of MN made by different polymers'combination. RESULTS The properties of MNs can be improve by combined ductile material(PVA, HPMC) and brittle materials(PVM/MA, PMVE/MAH and PVP K29/32). The formability and mechanical strength of MNs were significantly enhanced by adding more brittle material. Optimized combination of different polymers can promote the dissolution rate of MNs. CONCLUSION These results indicate the microneedles with appropriate ratio of ductile and brittle materials possess good formability, excellent mechanical strength and good skin adhesion.