| 活性氧自由基参与三氧化二砷心脏毒性的机制研究进展 |
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| 引用本文： | 王林娅,郑胡镛.活性氧自由基参与三氧化二砷心脏毒性的机制研究进展[J].中国药学杂志,2022,57(5):329-333. |
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| 作者姓名： | 王林娅 郑胡镛 |
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| 作者单位： | 国家儿童医学中心, 首都医科大学附属北京儿童医院血液病中心, 儿童血液病与肿瘤分子分型北京市重点实验室, 儿科学国家重点学科, 儿科重大疾病研究教育部重点实验室, 北京 100045 |
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| 基金项目： | 国家自然科学基金项目资助(82070154),国家科技重大专项-儿童重大疾病示范新药临床评价技术平台建设项目资助(017ZX09304029004);首都医科大学附属北京儿童医院儿童用药专项资助(YZZD202006) |
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| 摘 要： | 三氧化二砷(arsenic trioxide,As2O3)是目前国际上公认的治疗急性早幼粒细胞白血病的首选靶向药物之一,但As2O3导致的心脏毒性仍是临床面临的一个严峻问题.近年来,活性氧自由基参与As2O3心脏毒性的机制成为研究热点.活性氧自由基是As2O3诱导的心脏毒性机制的一个重要交互点,有望成为预防As2O3心...
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| 关 键 词： | 三氧化二砷 活性氧自由基 心脏毒性 |
| 收稿时间： | 2021-03-04 |
Advances in Research on the Mechanism of Reactive Oxygen Species in Arsenic Trioxide-Induced Cardiotoxicity |
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| WANG Lin-ya,ZHENG Hu-yong.Advances in Research on the Mechanism of Reactive Oxygen Species in Arsenic Trioxide-Induced Cardiotoxicity[J].Chinese Pharmaceutical Journal,2022,57(5):329-333. |
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| Authors: | WANG Lin-ya ZHENG Hu-yong |
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| Institution: | Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics, Hematology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China |
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| Abstract: | Arsenic trioxide is one of the first-line targeted drugs for the treatment of acute promyelocytic leukemia, however, arsenic trioxide-induced cardiotoxicity is still a serious clinical problem. Recently, the mechanism of reactive oxygen species involved in arsenic trioxide-induced cardiotoxicity is becoming a research hotspot. And reactive oxygen species is expected to become a target for preventing arsenic trioxide-induced cardiotoxicity since it plays an important role in the mechanism of arsenic trioxide-induced cardiotoxicity.This article reviewes the mechanism of reactive oxygen species involved in the arsenic trioxide-induced cardiotoxicity. |
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| Keywords: | arsenic trioxide reactive oxygen species cardiotoxicity |
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