| 非小细胞肺癌胸部放疗联合免疫治疗研究进展 |
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| 引用本文： | 许桐榛,梁军. 非小细胞肺癌胸部放疗联合免疫治疗研究进展[J]. 中华放射肿瘤学杂志, 2022, 31(6): 579-584. DOI: 10.3760/cma.j.cn113030-20211014-00405 |
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| 作者姓名： | 许桐榛 梁军 |
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| 作者单位： | 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京 100021;国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院放疗科,深圳 518116 |
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| 基金项目： | 中国医学科学院肿瘤医院深圳医院院内课题(SZ2020MS004) |
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| 摘 要： | 非小细胞肺癌(NSCLC)放疗联合免疫治疗,特别是联合PD-1/PD-L1免疫检查点抑制剂治疗,已成为近年来的研究焦点。探索放疗与免疫治疗的最优空间组合模式,实现各期患者最大限度的获益,是目前临床研究的方向之一。本文对放疗对肿瘤免疫环境的影响、各期NSCLC放疗联合免疫治疗进展以及存在的问题进行综述。
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| 关 键 词： | 癌 非小细胞肺 放射疗法 免疫疗法 研究进展 |
| 收稿时间： | 2021-10-14 |
Research progress on radiotherapy combined with immunotherapy for non-small cell lung cancer |
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| Xu Tongzhen,Liang Jun. Research progress on radiotherapy combined with immunotherapy for non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(6): 579-584. DOI: 10.3760/cma.j.cn113030-20211014-00405 |
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| Authors: | Xu Tongzhen Liang Jun |
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| Affiliation: | Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China |
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| Abstract: | Radiotherapy combined with immunotherapy for non-small cell lung cancer (NSCLC), especially with PD-1/PD-L1 immune checkpoint inhibitors, have fallen under the spotlight in recent years. How to explore the optimal combination modality of radiotherapy and immunotherapy to maximize the benefits for all-stage patients is one of the developing directions of clinical research. This article expounds the effect of radiotherapy on tumor immunology, research progress on radiotherapy combined with immunotherapy for various stages of NSCLC, and the problems existing in radiotherapy combined with immunotherapy. |
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| Keywords: | Carcinoma non-small-cell lung Radiotherapy Immunotherapy Research progress |
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