| 卒中后吞咽障碍的分子生物学研究进展 |
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| 引用本文： | 华晓琼,李彦杰,金小琴,刘昊源,张淑芹,牛丽. 卒中后吞咽障碍的分子生物学研究进展[J]. 中国卒中杂志, 2022, 17(3): 318-323. DOI: 10.3969/j.issn.1673-5765.2022.03.016 |
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| 作者姓名： | 华晓琼 李彦杰 金小琴 刘昊源 张淑芹 牛丽 |
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| 作者单位： | 1 郑州 450046河南中医药大学康复医学院2 河南省中医院康复科 |
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| 基金项目： | 河南省中医药科学研究专项课题（2019ZYBJ14）
河南省中医药拔尖人才培养项目（豫中医科教[2018]35号）
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| 摘 要： | 卒中后吞咽障碍是卒中后常见并发症,指患者由于卒中导致吞咽过程中的困难表现,其发生、发展的分子机制尚未阐明.调控吞咽功能的两个关键区域孤束核和疑核,其分泌的多种神经递质与吞咽功能密切相关.与孤束核密切相关的5-羟色胺(5-hydroxytryptamine,5-HT)及其受体5-HT1A、谷氨酸及N-甲基-D-天冬氨酸受...
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| 关 键 词： | 吞咽障碍 卒中 分子生物学 研究进展 |
| 收稿时间： | 2021-10-08 |
Advances in Molecular Biology of Post-Stroke Dysphagia |
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| HUA Xiaoqiong,LI Yanjie,JIN Xiaoqin,LIU Haoyuan,ZHANG Shuqin,NIU Li. Advances in Molecular Biology of Post-Stroke Dysphagia[J]. Chinese Journal of Stroke, 2022, 17(3): 318-323. DOI: 10.3969/j.issn.1673-5765.2022.03.016 |
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| Authors: | HUA Xiaoqiong LI Yanjie JIN Xiaoqin LIU Haoyuan ZHANG Shuqin NIU Li |
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| Abstract: | Post-stroke dysphagia is a common complication after stroke, which refers tothe difficulty in swallowing due to stroke. The molecular mechanism of post-stroke dysphagiaoccurrence and development has not been clarified. The nucleus tractus solitarius and nucleusambiguus, the two key regions of regulating swallowing function, can secrete a variety ofneurotransmitters which are closely related to swallowing function. The neurotransmitters such as5-HT and 5-HT1A receptors, glutamate (Glu) and NDMA receptors in nucleus tractus solitarius, andcalcitonin gene-related peptide (CGRP) and SOM, NOS neurons, glutamate, GABA in the nucleusambiguous, all play an important role in the initiation, control and related activities of swallowing.Combined with the latest achievements in the field of molecular biology, the possible pathogenesisof post-stroke dysphagia were elaborated in this article. |
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| Keywords: | Dysphagia Stroke Molecular biology Progress |
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