| 盐酸舍曲林预防性治疗卒中后抑郁的多中心研究 |
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| 引用本文： | 沈蓉,周华,赵中.盐酸舍曲林预防性治疗卒中后抑郁的多中心研究[J].中国卒中杂志,2022,17(5):510-515. |
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| 作者姓名： | 沈蓉 周华 赵中 |
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| 作者单位： | 苏州 215000南京医科大学附属苏州医院神经内科 |
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| 摘 要： | 目的 探讨缺血性卒中后早期应用盐酸舍曲林对卒中后抑郁（post-stroke depression，PSD）和认知功能障碍的影响。
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| 关 键 词： | 盐酸舍曲林 早期干预 缺血性卒中 卒中后抑郁 认知 |
| 收稿时间： | 2021-03-04 |
Efficacy of Sertraline Hydrochloride for Post-stroke Depression: A Multicenter Study |
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| SHEN Rong,ZHOU Hua,ZHAO Zhong.Efficacy of Sertraline Hydrochloride for Post-stroke Depression: A Multicenter Study[J].Chinese Journal of Stroke,2022,17(5):510-515. |
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| Authors: | SHEN Rong ZHOU Hua ZHAO Zhong |
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| Abstract: | Objective To investigate the effect of early application of sertraline on post-stroke depression (PSD)
and cognitive dysfunction after ischemic stroke.
Methods Patients with first acute ischemic stroke who were hospitalized in neurology department
of 6 hospitals in Suzhou from February 2016 to August 2017 were randomly divided into 3
groups: the control group was given conventional treatment, the low-dose treatment group was
given sertraline hydrochloride 50 mg/d on the basis of conventional treatment, and the high-dose
treatment group was given sertraline hydrochloride 100 mg/d on the basis of conventional treatment,
with the treatment course for 3 months. At 1 month, 3 months, 6 months and 1 year after stroke, the
patients were evaluated by Hamilton depression scale (HAMD), MMSE and mRS. The incidence
of PSD, cognitive function and prognosis at the above point-in-time and ischemic stroke recurrence
within one year were compared among the 3 groups.
Results A total of 404 patients were included in the final analysis, including 136 in control group,
140 in the low-dose treatment group, and 128 in the high-dose treatment group. (1) There were |
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| Keywords: | Sertraline hydrochloride Early intervention Ischemic stroke Post-stroke depression Cognition
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