多肽类药物在新生儿缺氧缺血性脑损伤中的研究进展

新生儿缺氧缺血性脑损伤是新生儿死亡和婴幼儿神经系统功能障碍的主要原因,目前唯一公认有效的治疗方法是亚低温治疗.近年来,随着新技术的发展,多肽类药物由于具有高选择性、高效性、耐受性好、制备简单、成本低等优点,得到了广泛关注.利用新生儿缺氧缺血性脑损伤模型的研究发现,多种多肽类药物可直接作用或通过与细胞穿膜肽结合进入神经细...

Research advances in peptide drugs in treatment of neonatal hypoxic ischemic brain injury

Neonatal hypoxic ischemic brain injury( HIBD) is the main cause of neonatal mortality and neurological dysfunction in infants. Until now,the hypothermia therapy is the only effective treatment of neonatal HIBD. In recent years,with the development of new technologies,peptide drugs have attracted extensive attention due to their advantages including high selectivity,high efficiency,excellent tolerability,simple preparation process and low cost. Using neonatal HIBD models,it was revealed that many kinds of peptide drugs could enter neurocytes directly or through combining with cell penetrating peptides and play roles of brain protection through inhibiting apoptosis,reducing excitotoxicity,improving mitochondrial permeability and so on. Peptide drugs may become new therapeutic approaches of neonatal HIBD. This article reviews the latest research advances in these peptide drugs and provides a new idea for the treatment of neonatal HIBD.