Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to Alzheimer's disease |
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| Authors: | Min-Yue Zhang Ling Miao Yan-Sheng Li Guang-Yuan Hu |
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| Affiliation: | 1. Department of Neurology, Ren Ji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 145 Shandong Road Middle, Shanghai, China;2. Department of English, Shanghai Jiaotong University School of Medicine, Shanghai, China;1. Department of Biology, Brigham Young University, Provo, UT, USA;2. ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA;3. Department of Family Consumer and Human Development, Utah State University, Logan, UT, USA;4. Center for Epidemiologic Studies, Utah State University, Logan, UT, USA;5. Department of Psychology, Utah State University, Logan, UT, USA;6. Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT, USA;7. Department of Mathematics and Statistics, Utah State University, Logan, UT, USA;1. Department of Biology, Brigham Young University, Provo, UT, USA;2. Department of Mathematics and Statistics, Utah State University, Logan, UT, USA;3. Center for Epidemiologic Studies, Utah State University, Logan, UT, USA;4. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA;5. Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA;6. Department of Family Consumer and Human Development, Utah State University, Logan, UT, USA;7. Department of Psychology, Utah State University, Logan, UT, USA;8. Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;9. Department of Nutrition Dietetics and Food Sciences, Utah State University, Logan, UT, USA;10. Department of Psychiatry, McGill University, Montreal, Quebec, Canada;11. Departments of Psychiatry and Medicine, Duke University, Durham, NC, USA;12. Department of Psychiatry, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA;1. Department of Neurology, Pomeranian Medical University, Szczecin, Poland;2. Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland;3. Department of Gynaecology and Urogynaecology, Pomeranian Medical University, Szczecin, Poland;1. Maternal, Fetal, Neonatal Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences, Iran;2. Breast Feeding Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran;3. Department of Biology, Payame Noor University, Iran;4. Nephrology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran;1. Department of Human Genetics and Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran;2. Department of Obstetrics & Gynecology, Sayyad Shirazi Hospital and Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran;3. Medical Cellular & Molecular Research Center, Talghani Children Hospital, Golestan University of Medical Sciences, Bolv Janbazan, Zip code: 4916668197 Gorgan, Iran;1. Genetics Research Center, Hartford Hospital, Hartford, Connecticut;2. Division of Metabolic and Bariatric Surgery, Hartford Hospital, Hartford, Connecticut;3. Genomas Inc., Hartford, Connecticut;4. University of Connecticut, School of Engineering, Storrs, Connecticut |
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| Abstract: | No clear consensus has been reached at the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and Alzheimer's disease (AD) risk. Thus in this meta-analysis, a total of 19 case–control studies was assessed to evaluate the possible association. The data demonstrated that the frequency of T677 allele (T vs. C) was significantly associated with susceptibility to AD in all subjects (OR = 1.15, 95% CI = 1.06–1.26) and in East Asians (OR = 1.22, 95% CI = 1.08–1.39). There was statistical difference between AD patients and the controls under recessive genetic mode (CT + TT vs. CC) and homozygote comparison (TT vs. CC) in all subjects and in East Asians as well. Despite a small effect of the polymorphism on late-onset AD (LOAD) risk, MTHFR C677T polymorphism was not a major risk factor for LOAD in East Asians and Caucasians. A subgroup analysis in the subjects without APOE ?4 alleles showed T677 allele significantly increased risk of AD in all subjects (OR = 1.21, 95% CI: 1.04–1.42) and in East Asians (OR = 1.28, 95% CI: 1.06–1.55). However, no association was found in Caucasians. In conclusion, this meta-analysis supports that MTHFR C677T polymorphism is capable of causing AD susceptibility in East Asians, not in Caucasians. |
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