羟基红花黄色素A对缺血性脑卒中神经保护作用及机制的研究进展

缺血性脑卒中是因血管栓塞导致局部脑血流急剧减少或中断引起的脑组织缺血缺氧损伤,常伴有严重的神经功能障碍。羟基红花黄色素A是活血化瘀药红花的主要成分之一。现代药理学研究发现,它在缺血性心脑血管疾病中发挥神经保护作用可缓解缺血再灌注造成的各种损伤,但其发挥作用的具体机制仍不清楚。通过检索红花在脑卒中应用的相关文献,笔者就羟基红花黄色素A在缺血性脑卒中发挥保护作用的机制包括抗氧化应激、抑制神经炎症反应、抗细胞凋亡、保护血脑屏障及促进突触可塑性等方面进行综述。以期为羟基红花黄色素A作为神经保护药物在脑卒中的临床应用中提供理论支持。

Research Progress on the Neuroprotective Mechanism of Hydroxysafflor Yellow A on Ischemic Stroke

Ischemic stroke is the ischemia and hypoxia damage of brain tissue caused by the rapid decrease or interruption of local cerebral blood flow caused by vascular embolism, and it is often accompanied by severe neurological dysfunction. Hydroxysafflor yellow A is one of the main components of safflower, a medicine for promoting blood circulation and removing blood stasis. Modern pharmacological studies have found that it exerts a neuroprotective effect in ischemic cardiovascular and cerebrovascular diseases and can alleviate various injuries caused by ischemia-reperfusion, but the specific mechanism of its action is still unclear. By searching the relevant literatures about the application of safflower yellow in stroke, this article discusses the mechanism of hydroxysafflor yellow A in ischemic stroke including anti-oxidative stress, inhibition of neuroinflammatory response,anti-apoptosis,and protecting the blood-brain barrier and the promotion of synaptic plasticity are reviewed. It is expected to provide theoretical support for the clinical application of hydroxysafflor yellow A as a neuroprotective drug in stroke.