Study of the adjuvanticity of lysine lipopeptides; carbamate analogs elicit strong Th1 and Th2 response to ovalbumin in mice |
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| Authors: | Ismail Tabasum Shafi Syed Gupta Amit Khajuria Anamika Sidiq Tabasum Reddy Doma Mahendhar Alam M Sarwar Qazi G N Kumar H M Sampath |
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| Affiliation: | aSynthetic and Biological Chemistry Division, Indian Institute of Integrative Medicine, Jammu 180001, India;bOrganic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India;cDepartment of Chemistry, Faculty of Science, Hamdard University, New Delhi 110062, India |
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| Abstract: | Bacterial lipoproteins and their synthetic analogs are strong immune modulators of the early host responses. In view of the strong adjuvanticity of bacterial lipopeptide mimics bearing lysine residues, a focused library of lipidated dipeptides and tripeptides has been synthesized with a view to understand the pattern of activity vis a vis the site and extent of lipidation. Compounds 4, 5 and 14 stimulate OVA specific IgG titer, neutralization of antibodies (IgG1 and IgG2a), T lymphocyte sub-sets (CD4/CD8) and its production of soluble mediators for Th1 (IFN-γ)/Th2 (IL-4) cytokines and costimulatory molecules (CD80/CD86) which are ideal traits of immune adjuvants. The results support lipidated lysine dipeptides as potent enhancers of humoral and cell mediated immune responses and thus might become promising immune-adjuvants for self adjuvanted vaccines. |
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| Keywords: | Adjuvants Lipopeptides Lysine Th1 |
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