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In vitro-clinical correlations for amphotericin B susceptibility in AIDS-associated cryptococcal meningitis |
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| Authors: | Larsen R A Bauer M Brouwer A E Sanchez A Thomas A M Rajanuwong A Chierakul W Peacock S J Day N White N J Rinaldi M G Harrison T S |
| Affiliation: | Department of Medicine (Infectious Diseases), 2020 Zonal Ave., IRD Room 620, MC 9520, University of Southern California, Los Angeles, CA 90033, USA. rlarsen@usc.edu |
| Abstract: | Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients. |
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