丹参川芎嗪注射液治疗不稳定型心绞痛137例临床观察

目的探讨丹参川芎嗪注射液治疗不稳定型心绞痛(unstable angina,UA)的疗效及安全性。方法将137例UA患者随机分为治疗组(72例)和对照组(65例),2组均给予常规抗凝、抗血小板、调脂、控制血压和/或血糖、血管紧张素转换酶抑制剂(或血管紧张素Ⅱ受体拮抗剂)、低分子肝素钙等治疗,治疗组在常规治疗的基础上,加用丹参川芎嗪注射液10mL,加入50¹00g·L-1葡萄糖注射液或生理盐水250100g·L-1葡萄糖注射液或生理盐水250⁵00mL中静脉滴注,1日1次,疗程15d。结果治疗组显效率为41.6%,有效率为50.0%,无效率为8.3%,总有效率为91.7%;对照组显效率为33.8%,有效率为40.0%,无效率为26.2%,总有效率为73.8%,2组总有效率差异有统计学意义(P<0.05)。治疗组较对照组治疗后心绞痛发作次数明显减少(1.3±1.2 vs.2.8±1.8次·d-1),心绞痛持续时间明显缩短(2.35±1.13 vs.5.28±1.98min),硝酸甘油用量明显减少(0.42±0.28 vs.0.78±0.23mg·d-1),心电图显示心肌缺血明显改善。结论在常规治疗的基础上,加用丹参川芎嗪注射液治疗UA疗效确切,使用简单,且长期应用未见明显不良反应,充分体现了丹参川芎嗪注射液治疗UA的优势。

Clinical observation of 137 cases by using Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in the treatment of unstable angina pectoris

Objective To investigate the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in the treatment of unstable angina pectoris （unstable angina ,UA） in the term of efficacy and safety .Methods 137 cases of UA patients were ran-domly divided into treatment group（72 cases） and control group（65 cases） .The two groups were given conventional anticoagula-tion ,antiplatelet ,lipid ,blood pressure control and/or glucose ,ACEI （or ARBⅡ） ,low molecular weight heparin calcium treatment . The treatment group was treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection 10 mL in 5-100 g · L^ -1 glu-cose injection or saline for 250-500 mL intravenous drip on the basis of conventional therapy ,once a day ,the course of treatment was 15 d .Results The efficiency of the treatment group was 41.6% ,effective rate was 50% ,no efficiency was 8.3% ,the total ef-fective rate was 91.7% ;the efficiency of the control group was 33 .8% ,efficiency was 40% ,no efficiency was 26 .2% ,the total ef-fective rate was 73 .8% ,the total efficiency of the two groups had significant difference （P＆lt;0 .05） .In the treatment group angina was significantly reduced （1 .3 ± 1 .2 vs .2 .8 ± 1 .8 ,once a day ） ,angina duration shortened significantly （2 .35 ± 1 .13 vs .5 .28 ± 1 . 98 min） ,the dosage of nitroglycerin was significantly reduced （0 .42 ± 0 .28 vs .0 .78 ± 0 .23 mg · d-1 ） ,and ECG showed myocardi-al ischemia significantly improved .Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection shows advantages in the treatment of UA .