Effect of Vaccinium bracteatum Thunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice |
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Authors: | Li Wang Xue Tong Zhang Hai Yan Zhang Hui Yuan Yao Hui Zhang |
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Affiliation: | 1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China;2. Wuxi No. 4 People''s Hospital, Wuxi 214062, Jiangsu, China |
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Abstract: | Aim of the studyTo investigate the hypoglycemic effects of Vaccinium bracteatum Thunb. leaves (VBTL) extract in streptozotocin-induced diabetic mice.Materials and methodsAfter administration of VBTL extract for 4 weeks, the body weight, organ weight, blood glucose (BG), insulin and plasma lipid levels of streptozotocin-induced diabetic mice were measured.ResultsBody weights of diabetic mice treated with VBTL extract were partly recovered. The BG levels of AEG (diabetic mice treated with VBTL aqueous extract) were reduced to 91.52 and 85.82% at week 2 and week 4, respectively (P < 0.05), while those of EEG (diabetic mice treated with VBTL ethanolic extract) were reduced slightly (P > 0.05). The insulin levels of AEG and EEG were obviously higher (P < 0.05) than those of MC (diabetic mice in model control group). Comparing with MC, AEG and EEG had significantly lower (P < 0.05) TC or TG levels and similar HDL-cholesterol or LDL-cholesterol levels. In comparison with non-diabetic control mice, AEG had similar plasma lipid levels except higher LDL-cholesterol level, while EEG had higher TC, TG and LDL-cholesterol levels and lower HDL-cholesterol levels.ConclusionsBoth aqueous and ethanolic extract of VBTL possess a potential hypoglycemic effect in streptozotocin-induced diabetic mice. |
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Keywords: | AEG, aqueous extract group, received 100 mg/kg body weight of water extract BG, blood glucose EEG, ethanolic extract group, received 100 mg/kg body weight of ethanol extract HDL, high density lipoprotein LDL, low density lipoprotein MC, model control, received isotonic saline solution NC, non-diabetic control mice group PC, positive control, received 500 mg/kg body weight of dimethylbiguanide STZ, streptozotocin TC, total cholesterol TG, triglyceride VBT, Vaccinium bracteatum Thunb. VBTL, Vaccinium bracteatum Thunb. leaves |
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