Evaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties |
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Authors: | Olivia Jansen L Angenot M Tits JP Nicolas P De Mol J-B Nikiéma M Frédérich |
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Institution: | 1. Laboratoire de Pharmacognosie, Centre Interfacultaire de Recherche du Médicament (CIRM), Université de Liège, Av. de I’Hôpital 1, CHU-B36, B-4000 Liège, Belgium;2. Association Jardins du Monde, 15, rue St Michel, 29190 Brasparts, France;3. Laboratoire de Microbiologie médicale, Université de Liège, Av. de I’Hôpital 1, B23, B-4000 Liège, Belgium;4. Unité de Formation et de Recherche en Sciences de la Santé, Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso;5. Direction de la promotion de la médecine et de la pharmacopée traditionnelle, Ministère de la Santé, 03 BP 7009, Ouagadougou 03, Burkina Faso |
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Abstract: | Aim of the studyThe aim of this study was to evaluate the antiplasmodial properties of 13 plants used against malaria in traditional medicine in Burkina Faso.Materials and methodsIn vitro antiplasmodial activity of dichloromethane, methanol and aqueous crude extracts obtained from vegetal samples collected in Burkina Faso was first evaluated on the Plasmodium falciparum 3D7 chloroquine-sensitive strain using a colorimetric method.ResultsThirteen extracts obtained from 8 different species were found to exhibit antiplasmodial activity (IC50 < 50 μg/ml). Five species demonstrated a moderate activity (15 μg/ml < IC50 < 50 μg/ml): Boswellia dalzielii (leaves), Waltheria indica (roots and aerial parts), Bergia suffruticosa (whole plant), Vitellaria paradoxa (bark) and Jatropha gossypiifolia (leaves). The best results were obtained with extracts from the Dicoma tomentosa whole plant, from Psorospermum senegalense leaves and from Gardenia sokotensis leaves. These extracts found to display promising antiplasmodial activity, with IC50 values ranging from 7.0 to 14.0 μg/ml.The most active plant extracts were then tested for in vitro activity on the Plasmodium falciparum W2 chloroquine-resistant strain and also for in vitro cytotoxicity on normal human fibroblasts (WI-38) in order to determine the selectivity index.ConclusionsDicoma tomentosa (Asteraceae) and Psorospermum senegalense (Clusiaceae) appeared to be the best candidates for further investigation of their antiplasmodial properties, reported for the first time by this study. |
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Keywords: | Malaria Antiplasmodial activity Dicoma tomentosa Psorospermum senegalense Burkina Faso Traditional medicine |
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